Comparison of Point-of-Care Testing and Hospital-Based Methods in Screening for Potential Type 2 Diabetes Mellitus and Abnormal Glucose Regulation in a Dental Setting

Muneedej Suwattipong, Thitima Thuramonwong, Chanita Tantipoj, Pornpoj Fuangtharnthip, Supanee Thanakun, Weerapan Khovidhunkit and Siribang-on Piboonniyom Khovidhunkit
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Muneedej Suwattipong: Dental Hospital, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
Thitima Thuramonwong: Dental Hospital, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
Chanita Tantipoj: Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
Pornpoj Fuangtharnthip: Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand
Supanee Thanakun: College of Dental Medicine, Rangsit University, Muang Pathum Thani 12000, Thailand
Weerapan Khovidhunkit: Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
Siribang-on Piboonniyom Khovidhunkit: Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand

IJERPH, 2021, vol. 18, issue 12, 1-12

Abstract: This study aimed to compare the screening methods between point-of-care (POC) testing and hospital-based methods for potential type 2 DM and abnormal glucose regulation (AGR) in a dental setting. A total of 274 consecutive subjects who attended the Faculty of Dentistry, Mahidol University, Bangkok, Thailand, were selected. Demographic data were collected. HbA 1c was assessed using a finger prick blood sample and analyzed with a point-of-care (POC) testing machine (DCA Vantage ® ). Hyperglycemia was defined as POC HbA 1c ? 5.7%. Random blood glucose (RBG) was also evaluated using a glucometer (OneTouch ® SelectSimple™) and hyperglycemia was defined as RBG ? 110 mg/dl or ?140 mg/dl. The subjects were then sent for laboratory measurements for fasting plasma glucose (FPG) and HbA 1c . The prevalence of AGR (defined as FPG ? 100 mg/dl or laboratory HbA 1c ? 5.7%) and potential type 2 DM (defined as FPG ? 126 mg/dl or laboratory HbA 1c ? 6.5%) among subjects was calculated and receiver operating characteristic (ROC) analysis was performed using FPG and HbA 1c for the diagnosis of AGR and potential type 2 DM. The prevalence of hyperglycemia defined as POC HbA 1c ? 5.7%, RBG ? 110 mg/dl, and RBG ? 140 mg/dl was 49%, 63%, and 32%, respectively. After the evaluation using laboratory measurements, the prevalence of AGR was 25% and 17% using laboratory FPG and HbA 1c criteria, respectively. Based on the ROC curves, the performances of POC HbA 1c and RBG in predicting FPG-defined potential type 2 DM were high (AUC = 0.99; 95% CI 0.98–0.99 and AUC = 0.94; 95% CI 0.86–1.0, respectively) but lower in predicting AGR (AUC = 0.72; 95% CI 0.67–0.78 and AUC = 0.65; 95% CI 0.59–0.70, respectively). This study suggested that POC testing might be a potential tool for screening of subjects with potential type 2 DM in a dental setting.

Keywords: point-of-care testing; diabetes mellitus; prevalence; dental clinics; hyperglycemia; abnormal glucose regulation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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