Free Fatty Acids Are Associated with the Cognitive Functions in Stroke Survivors

Dariusz Kotlęga, Barbara Peda, Joanna Palma, Agnieszka Zembroń-Łacny, Monika Gołąb-Janowska, Marta Masztalewicz, Przemysław Nowacki and Małgorzata Szczuko
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Dariusz Kotlęga: Department of Neurology, District Hospital, 67-200 Glogow, Poland
Barbara Peda: Department of Neurology, District Hospital, 67-200 Glogow, Poland
Joanna Palma: Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 71-460 Szczecin, Poland
Agnieszka Zembroń-Łacny: Department of Applied and Clinical Physiology, Collegium Medicum, University of Zielona Gora, 65-001 Zielona Góra, Poland
Monika Gołąb-Janowska: Department of Neurology, Pomeranian Medical University, 71-252 Szczecin, Poland
Marta Masztalewicz: Department of Neurology, Pomeranian Medical University, 71-252 Szczecin, Poland
Przemysław Nowacki: Department of Neurology, Pomeranian Medical University, 71-252 Szczecin, Poland
Małgorzata Szczuko: Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 71-460 Szczecin, Poland

IJERPH, 2021, vol. 18, issue 12, 1-15

Abstract: Ischemic stroke is a leading cause of motor impairment and psychosocial disability. Although free fatty acids (FFA) have been proven to affect the risk of stroke and potentially dementia, the evidence of their impact on cognitive functions in stroke patients is lacking. We aimed to establish such potential relationships. Seventy-two ischemic stroke patients were prospectively analysed. Their cognitive functions were assessed seven days post-stroke and six months later as follow-up ( n = 41). Seven days post-stroke analysis of serum FFAs levels showed direct correlations between Cognitive Verbal Learning Test (CVLT) and the following FFAs: C20:4n6 arachidonic acid and C20:5n3 eicosapentaenoic acid, while negative correlations were observed for C18:3n3 linolenic acid (ALA), C18:4 n3 stearidonic acid and C23:0 tricosanoic acid. Follow-up examination with CVLT revealed positive correlations with C15:0 pentadecanoid acid, C18:3n6 gamma linoleic acid, SDA, C23:0 tricosanoic acid and negative correlations with C14:0 myristic acid and C14:1 myristolenic acids. Several tests (Trail Making Test, Stroop Dots Trail, Digit Span Test and Verbal Fluency Test) were directly correlated mainly with C14:0 myristic acid and C14:1 myristolenic acid, while corresponding negatively with C18:1 vaccinic acid, C20:3n3 cis-11-eicosatrienoic acid, C22:1/C20:1 cis11- eicosanic acid and C20:2 cis-11-eicodienoic acid. No correlations between Montreal Cognitive Assessment (MOCA) test performed on seventh day, and FFAs levels were found. Saturated fatty acids play a negative role in long-term cognitive outcomes in stroke patients. The metabolic cascade of polyunsaturated fatty acids (n3 PUFA) and the synthesis of (AA) can be involved in pathogenesis of stroke-related cognitive impairment.

Keywords: ischemic stroke; dementia; risk factors; saturated fatty acids; polyunsaturated fatty acids; inflammation; lipids; cerebrovascular diseases; omega-3; cognitive decline; neuropsychological functions (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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