Genetic Variants in Smoking-Related Genes in Two Smoking Cessation Programs: A Cross-Sectional Study

Gloria Pérez-Rubio, Luis Alberto López-Flores, Ana Paula Cupertino, Francisco Cartujano-Barrera, Luz Myriam Reynales-Shigematsu, Mariana Ramírez, Edward F. Ellerbeck, Rosibel Rodríguez-Bolaños and Ramcés Falfan-Valencia
Additional contact information
Gloria Pérez-Rubio: HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Sección XVI, Mexico City 14080, Mexico
Luis Alberto López-Flores: HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Sección XVI, Mexico City 14080, Mexico
Ana Paula Cupertino: Department of Cancer Prevention and Control, Hackensack University Medical Center, Hackensack, NJ 07601, USA
Francisco Cartujano-Barrera: Department of Cancer Prevention and Control, Hackensack University Medical Center, Hackensack, NJ 07601, USA
Luz Myriam Reynales-Shigematsu: Department of Tobacco Research, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico
Mariana Ramírez: Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS 66160, USA
Edward F. Ellerbeck: Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, KS 66160, USA
Rosibel Rodríguez-Bolaños: Department of Tobacco Research, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico
Ramcés Falfan-Valencia: HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Calzada de Tlalpan 4502, Sección XVI, Mexico City 14080, Mexico

IJERPH, 2021, vol. 18, issue 12, 1-13

Abstract: Previous studies have identified variants in genes encoding proteins associated with the degree of addiction, smoking onset, and cessation. We aimed to describe thirty-one single nucleotide polymorphisms (SNPs) in seven candidate genomic regions spanning six genes associated with tobacco-smoking in a cross-sectional study from two different interventions for quitting smoking: (1) thirty-eight smokers were recruited via multimedia to participate in e-Decídete! program (e-Dec) and (2) ninety-four attended an institutional smoking cessation program on-site. SNPs genotyping was done by real-time PCR using TaqMan probes. The analysis of alleles and genotypes was carried out using the EpiInfo v7. on-site subjects had more years smoking and tobacco index than e-Dec smokers ( p < 0.05, both); in CYP2A6 we found differences in the rs28399433 ( p < 0.01), the e-Dec group had a higher frequency of TT genotype (0.78 vs. 0.35), and TG genotype frequency was higher in the on-site group (0.63 vs. 0.18), same as GG genotype (0.03 vs. 0.02). Moreover, three SNPs in NRXN1 , two in CHRNA3 , and two in CHRNA5 had differences in genotype frequencies ( p < 0.01). Cigarettes per day were different ( p < 0.05) in the metabolizer classification by CYP2A6 alleles. In conclusion, subjects attending a mobile smoking cessation intervention smoked fewer cigarettes per day, by fewer years, and by fewer cumulative pack-years. There were differences in the genotype frequencies of SNPs in genes related to nicotine metabolism and nicotine dependence. Slow metabolizers smoked more cigarettes per day than intermediate and normal metabolizers.

Keywords: nicotine addiction; smoking cessation; CHRNA3; CHRNA5; NRXN1; DRD4; HTR2A; CYP2A6; e-Decídete (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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