Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Lilian Calderón-Garcidueñas, Ravi Philip Rajkumar, Elijah W. Stommel, Randy Kulesza, Yusra Mansour, Adriana Rico-Villanueva, Jorge Orlando Flores-Vázquez, Rafael Brito-Aguilar, Silvia Ramírez-Sánchez, Griselda García-Alonso, Diana A. Chávez-Franco, Samuel C. Luévano-Castro, Edgar García-Rojas, Paula Revueltas-Ficachi, Rodolfo Villarreal-Ríos and Partha S. Mukherjee
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Lilian Calderón-Garcidueñas: Department of Biomedical & Pharmaceutical Sciences, College of Health, The University of Montana, Missoula, MT 59812, USA
Ravi Philip Rajkumar: Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India
Elijah W. Stommel: Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA
Randy Kulesza: Auditory Research Center, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA
Yusra Mansour: Henry Ford Macomb, Department of Otolaryngology—Facial Plastic Surgery, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA
Adriana Rico-Villanueva: Universidad del Valle de México, Mexico City 14370, Mexico
Jorge Orlando Flores-Vázquez: Universidad del Valle de México, Mexico City 14370, Mexico
Rafael Brito-Aguilar: Universidad del Valle de México, Mexico City 14370, Mexico
Silvia Ramírez-Sánchez: Universidad del Valle de México, Mexico City 14370, Mexico
Griselda García-Alonso: Universidad del Valle de México, Mexico City 14370, Mexico
Diana A. Chávez-Franco: Universidad del Valle de México, Mexico City 14370, Mexico
Samuel C. Luévano-Castro: Universidad del Valle de México, Mexico City 14370, Mexico
Edgar García-Rojas: Universidad del Valle de México, Mexico City 14370, Mexico
Paula Revueltas-Ficachi: Universidad del Valle de México, Mexico City 14370, Mexico
Rodolfo Villarreal-Ríos: Universidad Autónoma de Piedras Negras, Piedras Negras 26000, Mexico
Partha S. Mukherjee: Interdisciplinary Statistical Research Unit, Indian Statistical Institute, Kolkata 700108, India

IJERPH, 2021, vol. 18, issue 13, 1-13

Abstract: Quadruple aberrant hyperphosphorylated tau (p-?), amyloid-? peptide, alpha-synuclein and TDP-43 brainstem and supratentorial pathology are documented in forensic ?40y autopsies in Metropolitan Mexico City (MMC), and p-? is the major aberrant protein. Post-traumatic stress disorder (PTSD) is associated with an elevated risk of subsequent dementia, and rapid eye movement sleep behavior disorder (RBD) is documented in PD, AD, Lewy body dementia and ALS. This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale–Revised (IES-R) and pRBD symptoms using the RBD Single-Question. Over 50% of the participants had IES-R scores ?33 indicating probable PTSD. pRBD was identified in 22.6% of the participants across Mexico and 32.7% in MMC residents with PTSD. MMC subjects with PTSD had an OR 2.6218 [2.5348, 2.7117] of answering yes to the pRBD. PTSD and pRBD were more common in women. This study showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites. We need to confirm the RBD diagnosis using an overnight polysomnogram. Mexican women are at high risk for stress and sleep disorders.

Keywords: Alzheimer; dementia; quadruple proteinopathies; nanoparticles; post-traumatic stress disorder; PTSD; possible REM sleep behavior disorder; pRBD; TDP-43 proteinopathies; Parkinson; Mexico (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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