Anti-TNF-Related Leukocytoclastic Vasculitis in Ulcerative Colitis: A Case Report

Valentina Giorgio, Elisa Blasi, Donato Rigante, Cristina Guerriero, Clara De Simone, Anna Laura Fedele, Giuseppe Stella, Antonio Gasbarrini and Franco Scaldaferri
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Valentina Giorgio: Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Elisa Blasi: Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Donato Rigante: Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Cristina Guerriero: Institute of Dermatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Clara De Simone: Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Anna Laura Fedele: Institute of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Giuseppe Stella: Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Antonio Gasbarrini: Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Franco Scaldaferri: Department of Internal Medicine, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy

IJERPH, 2021, vol. 18, issue 13, 1-6

Abstract: Background: The development of drugs directed against tumor necrosis factor (TNF)-? has dramatically modified the therapeutic approach to inflammatory bowel diseases: a larger use of such drugs has also led to a major knowledge about their adverse effects, especially on skin. The aim of this report was to describe a rare steroid-dependent form of leukocytoclastic vasculitis induced by an anti-TNF-? agent in a young woman with ulcerative colitis. Case presentation: A young girl with ulcerative colitis developed a form of leukocytoclastic vasculitis induced by an anti-TNF-? agent. Recurrent palpable purpuric lesions on her legs were the main cutaneous manifestation. Skin lesions were steroid-dependent, but improved after withdrawal of the anti-TNF-? agent and second-line immunosuppressant therapy. Conclusions: The need to develop specific recommendations to guide the use of medications for managing skin reactions induced by anti-TNF-? drugs is herein emphasized.

Keywords: leukocytoclastic vasculitis; ulcerative colitis; purpura; tumor necrosis factor (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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