Association between GnRH Receptor Polymorphisms and Luteinizing Hormone Levels for Low Ovarian Reserve Infertile Women

Shun-Long Weng, Shu-Ling Tzeng, Chun-I Lee, Chung-Hsien Liu, Chun-Chia Huang, Shun-Fa Yang, Maw-Sheng Lee and Tsung-Hsien Lee
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Shun-Long Weng: Department of Obstetrics and Gynecology, Hsinchu MacKay Memorial Hospital, Hsinchu 30071, Taiwan
Shu-Ling Tzeng: Institute of Medicine, Chung Shan Medical University, Taichung 40203, Taiwan
Chun-I Lee: Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan
Chung-Hsien Liu: Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung 40203, Taiwan
Chun-Chia Huang: Division of Infertility Clinic, Lee Women’s Hospital, Taichung 40602, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 40203, Taiwan
Maw-Sheng Lee: Institute of Medicine, Chung Shan Medical University, Taichung 40203, Taiwan
Tsung-Hsien Lee: Institute of Medicine, Chung Shan Medical University, Taichung 40203, Taiwan

IJERPH, 2021, vol. 18, issue 13, 1-11

Abstract: The choice of ovarian stimulation protocols in assisted reproduction technology (ART) cycles for low ovarian reserve patients is challenging. Our previous report indicated that the gonadotrophin-releasing (GnRH) agonist (GnRHa) protocol is better than the GnRH antagonist (GnRHant) protocol for young age poor responders. Here, we recruited 269 patients with anti-Müllerian hormone ( AMH ) < 1.2 ng/mL undergoing their first ART cycles for this nested case-control study. We investigated the genetic variants of the relevant genes, including follicular stimulating hormone receptor ( FSHR ; rs6166), AMH (rs10407022), GnRH (rs6185), and GnRH receptor ( GnRHR ; rs3756159) in patients <35 years ( n = 86) and patients ?35 years of age ( n = 183). Only the genotype of GnRHR (rs3756159) is distributed differently in young (CC 39.5%, CT/TT 60.5%) versus advanced (CC 24.0%, CT/TT 76.0%) age groups (recessive model, p = 0.0091). Furthermore, the baseline luteinizing hormone (LH) levels (3.60 (2.45 to 5.40) vs. 4.40 (2.91 to 6.48)) are different between CC and CT/TT genotype of GnRHR (rs3756159). In conclusion, the genetic variants of GnRHR (rs3756159) could modulate the release of LH in the pituitary gland and might then affect the outcome of ovarian stimulation by GnRHant or GnRHa protocols for patients with low AMH levels.

Keywords: GnRH receptor; anti-Müllerian hormone; assisted reproduction technology; single nucleotide polymorphism; poor responders; POSEIDON criteria; GnRH antagonist; GnRH agonist (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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