Advanced Glycation End Products: New Clinical and Molecular Perspectives

Juan Salazar, Carla Navarro, Ángel Ortega, Manuel Nava, Daniela Morillo, Wheeler Torres, Marlon Hernández, Mayela Cabrera, Lissé Angarita, Rina Ortiz, Maricarmen Chacín, Luis D’Marco and Valmore Bermúdez
Additional contact information
Juan Salazar: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
Carla Navarro: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
Ángel Ortega: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
Manuel Nava: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
Daniela Morillo: Faculty of Medicine, School of Medicine, University of Buenos Aires, Buenos Aires 1121, Argentina
Wheeler Torres: Endocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
Marlon Hernández: Faculty of Medicine, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela
Mayela Cabrera: City of Houston Health Department, Houston, TX 77054, USA
Lissé Angarita: Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Andrés Bello, Sede Concepción 4260000, Chile
Rina Ortiz: Facultad de Medicina, Universidad Católica de Cuenca, Cuenca 010105, Ecuador
Maricarmen Chacín: Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia
Luis D’Marco: Department of Nephrology, Hospital Clinico Universitario de Valencia, INCLIVA, University of Valencia, 46010 Valencia, Spain
Valmore Bermúdez: Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia

IJERPH, 2021, vol. 18, issue 14, 1-24

Abstract: Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF). Hence, this study aimed to establish an update about the molecular mechanisms induced by AGEs during the evolution of chronic complications of DM and describe the newer measurement techniques available, highlighting SAF as a possible tool to measure the risk of developing DM chronic complications.

Keywords: advanced glycation end products; diabetes mellitus; chronic complications; skin fluorescence (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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