Quantitation of Silica Contents in Lung Explants of Transplanted Patients: Artificial Stone-Induced Silicosis vs. Idiopathic Pulmonary Fibrosis

Elizabeth Fireman, Abed Elrahman Mahamed, Dror Rosengarten, Noa Noach Ophir and Mordechai Reuven Kramer
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Elizabeth Fireman: Laboratory for Pulmonary and Allergic Diseases, Tel-Aviv Medical Centre, Tel-Aviv 6423906, Israel
Abed Elrahman Mahamed: Laboratory for Pulmonary and Allergic Diseases, Tel-Aviv Medical Centre, Tel-Aviv 6423906, Israel
Dror Rosengarten: Institute of Pulmonary Diseases, Rabin Medical Centre, Petah Tekvah 4947492, Israel, both affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel
Noa Noach Ophir: Laboratory for Pulmonary and Allergic Diseases, Tel-Aviv Medical Centre, Tel-Aviv 6423906, Israel
Mordechai Reuven Kramer: Institute of Pulmonary Diseases, Rabin Medical Centre, Petah Tekvah 4947492, Israel, both affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel

IJERPH, 2021, vol. 18, issue 14, 1-8

Abstract: Spectrophotometric techniques provide qualitative but not quantitative data on lung particles. We aimed to quantitate silica content in biopsies of lung-transplanted silicosis patients by applying X-ray fluorescence (XRF) spectrometry. Lung biopsies of 17 lung-transplanted artificial patients were quantitated for silica and other minerals particles by Niton XL3 XRF spectrometry. Occupational and clinical history data were assessed. Lung biopsies of artificial stone-induced silicosis (ASIS) patients contained significantly higher levels of silica compared to those of idiopathic pulmonary fibrosis (IPF) patients (7284.29 ± 4693.75 ppm vs. 898.88 ± 365.66 ppm, p < 0.0001). Silica content correlated negatively with age, body mass index, and pulmonary function test results. A 1128 ppm silica cut-off value yielded 100% sensitivity and 94% specificity for predicting ASIS (AUC = 0.94, p < 0.0001). In conclusion, XRF measurements in lung biopsies can differentiate between silica and mineral particles in ASIS and IPF.

Keywords: artificial stone-induced silicosis; X-ray fluorescence; quantitation of silica (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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