Can Physical Activity Reduce the Risk of Cognitive Decline in Apolipoprotein e4 Carriers? A Systematic Review

Jose Luis Perez-Lasierra, Jose Antonio Casajús, José Antonio Casasnovas, Jose Miguel Arbones-Mainar, Antonio Lobo, Elena Lobo, Belén Moreno-Franco and Alejandro Gonzalez-Agüero
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Jose Luis Perez-Lasierra: Department of Physiatry and Nursing, Universidad de Zaragoza, 50009 Zaragoza, Spain
Jose Antonio Casajús: Department of Physiatry and Nursing, Universidad de Zaragoza, 50009 Zaragoza, Spain
José Antonio Casasnovas: Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
Jose Miguel Arbones-Mainar: CIBEROBN Instituto de Salud Carlos III, 28029 Madrid, Spain
Antonio Lobo: Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
Elena Lobo: Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
Belén Moreno-Franco: Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
Alejandro Gonzalez-Agüero: Department of Physiatry and Nursing, Universidad de Zaragoza, 50009 Zaragoza, Spain

IJERPH, 2021, vol. 18, issue 14, 1-15

Abstract: Physical activity (PA) reduces the risk of cognitive decline (CD) in the general population. However, little is known about whether the presence of the apolipoprotein E epsilon 4 allele ( APOE e4 ) could modify this beneficial effect. The aim of this systematic review was to analyze and synthetize the scientific evidence related to PA levels and CD risk in cognitively healthy APOE e4 carriers. Four electronic databases were analyzed. Only original articles with longitudinal study design were selected to analyze the relationship between PA and CD in APOE e4 carriers. Five studies were included in the systematic review. All studies except one stated that PA is a protective factor against CD in APOE e4 carriers. Moreover, partial support was found for the hypothesis that a greater amount and intensity of PA are more beneficial in CD prevention. The results support the idea that PA is a protective factor against CD in APOE e4 carriers. Nevertheless, it would be necessary to carry out further studies that would allow these findings to be contrasted.

Keywords: exercise; APOE e4; Cognitive Dysfunction; mild cognitive impairment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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