A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis

Itxaso González-Ortega, Patricia Vega, Enrique Echeburúa, Susana Alberich, Jessica Fernández-Sevillano, Sara Barbeito, Vicent Balanzá-Martínez, Eduard Vieta, Esther Lorente-Rovira, Ana Luengo, Ester Cerrillo, José Manuel Crespo, Carlos Matute and Ana González-Pinto
Additional contact information
Itxaso González-Ortega: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Patricia Vega: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Enrique Echeburúa: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Susana Alberich: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Jessica Fernández-Sevillano: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Sara Barbeito: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Vicent Balanzá-Martínez: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Eduard Vieta: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Esther Lorente-Rovira: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Ana Luengo: Department of Psychiatry, Clinic University Hospital of Valencia, INCLIVA, 46010 Valencia, Spain
Ester Cerrillo: Department of Psychiatry, Bellvitge University Hospital, IDIBELL, 08907 Barcelona, Spain
José Manuel Crespo: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain
Carlos Matute: Achucarro Basque Centre for Neurosciences, University of the Basque Country, 48940 Leioa, Spain
Ana González-Pinto: Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain

IJERPH, 2021, vol. 18, issue 14, 1-13

Abstract: Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The aim of this study was to compare the efficacy of a combined clinical treatment involving Cognitive Behavioural Therapy (CBT) as an adjunctive to treatment-as-usual (TAU) (CBT+TAU) versus TAU alone for FEP. Patients and methods: In this multicentre, single-blind, randomised controlled trial, 177 participants were randomly allocated to either CBT+TAU or TAU. The primary outcome was post-treatment patient functioning. Results: The CBT+TAU group showed a greater improvement in functioning, which was measured using the Global Assessment Functioning (GAF) and Functioning Assessment Short Test (FAST), compared to the TAU group post-treatment. The CBT+TAU participants exhibited a greater decline in depressive, negative, and general psychotic symptoms; a better awareness of the disease and treatment adherence; and a greater increase in brain-derived neurotrophic factor levels than TAU participants. Conclusions: Early intervention based on a combined clinical treatment involving CBT as an adjunctive to standard treatment may improve clinical and functional outcomes in FEP.

Keywords: first-episode psychosis; early intervention; treatment; outcome; randomised controlled trial (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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