Anti-HIV and Anti-Candidal Effects of Methanolic Extract from Heteropterys brachiata

Maira Huerta-Reyes, Luis O. Sánchez-Vargas, Getsemaní S. Villanueva-Amador and Luis A. Gaitán-Cepeda
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Maira Huerta-Reyes: Unidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México 06720, Mexico
Luis O. Sánchez-Vargas: Laboratorio de Bioquímica y Microbiología Oral, Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78290, Mexico
Getsemaní S. Villanueva-Amador: Departamento de Medicina y Patología Oral y Maxilofacial, División de Estudios de Postgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Circuito Institutos s/n, Ciudad Universitaria, Coyoacán, Ciudad de México 04510, Mexico
Luis A. Gaitán-Cepeda: Departamento de Medicina y Patología Oral y Maxilofacial, División de Estudios de Postgrado e Investigación, Facultad de Odontología, Universidad Nacional Autónoma de México, Circuito Institutos s/n, Ciudad Universitaria, Coyoacán, Ciudad de México 04510, Mexico

IJERPH, 2021, vol. 18, issue 14, 1-7

Abstract: Nowadays, the HIV pandemic is far from controlled. HIV+/AIDS patients show a serious risk of developing resistance to HIV antiretroviral drugs and to be orally colonized by albicans and non- albicans Candida strains resistant to antifungals. As a consequence, new drugs that possess anti-candidal and anti-HIV effects would represent an alternative in the comprehensive treatment of HIV+/AIDS patients. The present study evaluates the possible anti-HIV and anti- Candida effects of a methanolic extract from Heteropterys brachiata (Hb MeOH), an American tropical plant. The anti-HIV effect of Hb MeOH was tested using a non-radioactive colorimetric method (Lenti RT ® Activity Assay; Cavidi Tech) that uses reverse transcriptase of HIV-1 enzyme as enzymatic target. The anti-candidal effect of HbMeOH extract was evaluated by following a standardized test protocol of microdilution for yeast using the Candida albicans strain ATCC ® 90028. The Hb MeOH at 1 mg/mL concentration shows 38.5% RT-HIV inhibition, while Hb MeOH at 10 mg/mL concentration produced 98% C. albicans growth inhibition. Our findings show that the Hb MeOH possesses a strong anti-candidal activity and moderate anti-HIV effect and suggests that the plant extract could be considered as a potential candidate for HIV/AIDS treatment.

Keywords: HIV; AIDS; candidiasis; antiretroviral treatment; antifungal treatment; Heteropterys; Malpighiaceae (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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