Bioactive Compounds of Porcine Hearts and Aortas May Improve Cardiovascular Disorders in Humans

Irina Chernukha, Elena Kotenkova, Svetlana Derbeneva and Daniil Khvostov
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Irina Chernukha: V. M. Gorbatov Federal Research Center for Food Systems of RAS, Experimental Clinic and Research Laboratory for Bioactive Substances of Animal Origin, Talalikhina St. 26, Moscow 109316, Russia
Elena Kotenkova: V. M. Gorbatov Federal Research Center for Food Systems of RAS, Experimental Clinic and Research Laboratory for Bioactive Substances of Animal Origin, Talalikhina St. 26, Moscow 109316, Russia
Svetlana Derbeneva: Federal Research Center of Nutrition, Biotechnology and Food Safety, Department of Cardiovascular Pathology, Kashirskoe Sh. 21, Moscow 115446, Russia
Daniil Khvostov: V. M. Gorbatov Federal Research Centre for Food Systems of RAS, Laboratory of Molecular Biology and Bioinformatics, Talalikhina St. 26, Moscow 109316, Russia

IJERPH, 2021, vol. 18, issue 14, 1-18

Abstract: Functional foods promote health benefits in human metabolism, with bioactive compounds acting as therapeutic agents. The aim was to investigate the biological effects of a pâté made of pork hearts and aortas, minced, sterilised and packed in tins. Adults (61–66 years old) with a body mass index of 26.4–60.7 kg/m 2 (n = 36) were randomly divided into two groups: one group consumed a low-calorie diet (LCD), while the other consumed an LCD with the developed meat product (MP) for 28–30 days. Serum biochemical parameters, anthropometry and blood pressure were measured. Consumption of an LCD + MP by experimental group participants helped to maintain reduced cholesterol levels. The difference in total cholesterol was significantly different ( p = 0.018) from that of the control group, mainly due to the difference in low-density lipoprotein cholesterol ( p = 0.005). Six peptides with potential cholesterol-binding properties and four peptides with potential antioxidant activity were identified in the MP, while elevation of the content of two peptides with potential angiotensin-converting enzyme-inhibitory activity was detected in patients’ plasma. Intervention with the MP can be considered as a supportive therapy to the main treatment for medical cardiovascular diseases due to a positive effect on serum cholesterol.

Keywords: hyperlipidaemia; hypertension; cholesterol; bioactive peptides; trial (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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