DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk

Mirosław Śnit, Maciej Misiołek, Wojciech Ścierski, Anna Koniewska, Grażyna Stryjewska-Makuch, Sławomir Okła and Władysław Grzeszczak
Additional contact information
Mirosław Śnit: Department and Clinic of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, 41-800 Zabrze, Poland
Maciej Misiołek: Department of Otorhinolaryngology and Laryngological Oncology, Medical University of Silesia, 41-800 Zabrze, Poland
Wojciech Ścierski: Department of Otorhinolaryngology and Laryngological Oncology, Medical University of Silesia, 41-800 Zabrze, Poland
Anna Koniewska: Department of Otorhinolaryngology and Laryngological Oncology, Medical University of Silesia, 41-800 Zabrze, Poland
Grażyna Stryjewska-Makuch: Department of Laryngology and Laryngological Oncology, Upper Silesian Medical Centre of Silesian Medical University, 40-055 Katowice, Poland
Sławomir Okła: Department of Otolaryngology, Head and Neck Surgery, Holy-Cross Cancer Center, 25-734 Kielce, Poland
Władysław Grzeszczak: Department of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, ul. 3. Maja 13-15, 41-800 Zabrze, Poland

IJERPH, 2021, vol. 18, issue 14, 1-9

Abstract: AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. PATIENTS AND METHODS: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. RESULTS: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. CONCLUSIONS: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.

Keywords: DIAPH2; PTPRD and HIC1 gene polymorphisms; laryngeal cancer risk (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/14/7486/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/14/7486/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:14:p:7486-:d:593655

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().