Deep Venous Thrombosis and Risk of Consequent Sepsis Event: A Retrospective Nationwide Population-Based Cohort Study

Ying-Tung Yeh, Sheng-En Tsai, Ying-Cheng Chen, Shun-Fa Yang, Han-Wei Yeh, Bo-Yuan Wang, Liang-Tsai Yeh, Nai-Chen Shih, Yu-Hsun Wang, Yin-Yang Chen and Chao-Bin Yeh
Additional contact information
Ying-Tung Yeh: Graduate School of Dentistry, School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
Sheng-En Tsai: Department of Anesthesiology, Changhua Christian Hospital, Changhua 50006, Taiwan
Ying-Cheng Chen: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Han-Wei Yeh: School of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan
Bo-Yuan Wang: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Liang-Tsai Yeh: Department of Anesthesiology, Changhua Christian Hospital, Changhua 50006, Taiwan
Nai-Chen Shih: Department of Family Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Yu-Hsun Wang: Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
Yin-Yang Chen: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Chao-Bin Yeh: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

IJERPH, 2021, vol. 18, issue 15, 1-11

Abstract: Deep vein thrombosis causes several acute and chronic vessel complications and puts patients at risk of subsequent sepsis development. This unique study aimed to estimate the risk of sepsis development in DVT patients compared with non-DVT patients. This population-based cohort study used records of a longitudinal health insurance database containing two million patients defined in Taiwan’s National Health Insurance Research Database (NHIRD). Our study included patients aged over 20 years with a new diagnosis of DVT with at least two outpatient department visits or an admission between 2001 and 2014. Patients with a diagnosis of sepsis before the index date were excluded. Propensity score matching (PSM) was used to homogenize the baseline characteristics between the two groups. To define the independent risk of the DVT group, a multivariate Cox proportional hazard model was used to estimate the hazard ratios. After PSM, the DVT group ( n = 5753) exhibited a higher risk of sepsis (adjusted hazard ratio, aHR, 1.74; 95% CI, 1.59–1.90) compared with non-DVT group ( n = 5753). Patients with an increased risk of sepsis were associated with being elderly aged, male, having diabetes, chronic kidney disease, chronic obstructive pulmonary disease, stroke, malignancy, and use of antibiotics. In conclusion, this population-based cohort study demonstrated an increased risk of sepsis in DVT patients compared with non-DVT patients. Thus, early prevention and adequate treatment of DVT is necessary in clinical practice.

Keywords: sepsis; deep vein thrombosis; cohort study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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