The Influence of Traffic-Related Air Pollution (TRAP) in Primary Schools and Residential Proximity to Traffic Sources on Histone H3 Level in Selected Malaysian Children

Nur Faseeha Suhaimi, Juliana Jalaludin and Suhaili Abu Bakar
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Nur Faseeha Suhaimi: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia
Juliana Jalaludin: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia
Suhaili Abu Bakar: Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia

IJERPH, 2021, vol. 18, issue 15, 1-19

Abstract: This study aimed to investigate the association between traffic-related air pollution (TRAP) exposure and histone H3 modification among school children in high-traffic (HT) and low-traffic (LT) areas in Malaysia. Respondents’ background information and personal exposure to traffic sources were obtained from questionnaires distributed to randomly selected school children. Real-time monitoring instruments were used for 6-h measurements of PM 10 , PM 2.5 , PM 1 , NO 2 , SO 2 , O 3 , CO, and total volatile organic compounds (TVOC). Meanwhile, 24-h measurements of PM 2.5 -bound black carbon (BC) were performed using air sampling pumps. The salivary histone H3 level was captured using an enzyme-linked immunosorbent assay (ELISA). HT schools had significantly higher PM 10 , PM 2.5 , PM 1 , BC, NO 2 , SO 2 , O 3 , CO, and TVOC than LT schools, all at p < 0.001. Children in the HT area were more likely to get higher histone H3 levels ( z = ?5.13). There were positive weak correlations between histone H3 level and concentrations of NO 2 ( r = 0.37), CO ( r = 0.36), PM 1 ( r = 0.35), PM 2.5 ( r = 0.34), SO 2 ( r = 0.34), PM 10 ( r = 0.33), O 3 ( r = 0.33), TVOC ( r = 0.25), and BC ( r = 0.19). Overall, this study proposes the possible role of histone H3 modification in interpreting the effects of TRAP exposure via non-genotoxic mechanisms.

Keywords: traffic-related air pollution; primary schools; vulnerable population; indoor air quality; histone H3 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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