TB Antigen-Stimulated CXCR3 Ligand Assay for Diagnosis of Tuberculous Lymphadenitis

Wou-Young Chung, Keu-Sung Lee, Joo-Hun Park, Yun-Jung Jung, Seung-Soo Sheen, Ji-Eun Park, Joo-Sung Sun, Young-Hwa Ko and Kwang-Joo Park
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Wou-Young Chung: Department of Pulmonology and Critical Care Medicine, Ajou University Hospital, Suwon 16499, Korea
Keu-Sung Lee: Department of Pulmonology and Critical Care Medicine, Ajou University Hospital, Suwon 16499, Korea
Joo-Hun Park: Department of Pulmonology and Critical Care Medicine, Ajou University Hospital, Suwon 16499, Korea
Yun-Jung Jung: Department of Pulmonology and Critical Care Medicine, Ajou University Hospital, Suwon 16499, Korea
Seung-Soo Sheen: Department of Pulmonology and Critical Care Medicine, Ajou University Hospital, Suwon 16499, Korea
Ji-Eun Park: Department of Pulmonology and Critical Care Medicine, Ajou University Hospital, Suwon 16499, Korea
Joo-Sung Sun: Department of Radiology, Ajou University Hospital, Suwon 16499, Korea
Young-Hwa Ko: Department of Pathology, Ajou University Hospital, Suwon 16499, Korea
Kwang-Joo Park: Department of Pulmonology and Critical Care Medicine, Ajou University Hospital, Suwon 16499, Korea

IJERPH, 2021, vol. 18, issue 15, 1-14

Abstract: The diagnosis of tuberculous lymphadenitis (TB-LAP) is challenging. We evaluated the role of blood CXC chemokine receptor 3 (CXCR3) ligands in its diagnosis. A total of 65 lymphadenopathy patients were enrolled and lymph node sampling was performed. We also recruited 113 control subjects, consisting of 27 with positive results and 86 with negative results, in the interferon (IFN)-? release assay (IGRA). In all study subjects, whole-blood samples were collected using the IGRA methodology. After incubation, plasma levels of IFN-? and two CXCR3 ligands, IFN-inducible T-cell a chemoattractant (I-TAC) and monokine induced by IFN-? (MIG), were measured using immunoassay. Fifty-three TB-LAP patients were enrolled. TB antigen-stimulated IFN-?, I-TAC, and MIG levels were all significantly higher in the TB-LAP patients than in the controls and non-TB-LAP patients. The levels of I-TAC and MIG, but not IFN-?, showed significant differences between the TB-LAP patients and IGRA-positive controls. Area under the receiver operating characteristic curves (AUROCs) of IFN-?, I-TAC, and MIG were 0.955, 0.958, and 0.959, respectively, for differentiating TB-LAP from control group, and were 0.912, 0.956, and 0.936, respectively, for differentiating TB-LAP from non-TB-LAP. In conclusion, the TB antigen-stimulated MIG and I-TAC could be useful biomarkers in the diagnosis of TB-LAP.

Keywords: tuberculosis; tuberculous lymphadenitis; CXCR3 ligand (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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