In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes

Samy M. El-Megharbel, Moamen S. Refat, Fawziah A. Al-Salmi and Reham Z. Hamza
Additional contact information
Samy M. El-Megharbel: Department of Chemistry, College of Science, Zagazig University, Zagazig 44519, Egypt
Moamen S. Refat: Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Fawziah A. Al-Salmi: Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Reham Z. Hamza: Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

IJERPH, 2021, vol. 18, issue 15, 1-19

Abstract: Magnesium(II), calcium(II), chromium(III), zinc(II), copper(II), and selenium(IV) sitagliptin (STG) complexes—with the general formulas [Mg(STG) 2 (Cl) 2 ]·6H 2 O, [Ca(STG) 2 (Cl) 2 ], [Cr(STG) 2 (Cl) 2 ]Cl.6H 2 O, [Zn(STG) 2 (Cl) 2 ], [Cu(STG) 2 (Cl) 2 ]·2H 2 O, and [Se(STG) 2 (Cl) 2 ]Cl 2 , respectively—were designed and synthesized by the chemical reactions between metal(II, III, and IV) chloride salts with an STG ligand in situ methanol solvent in a 1:2 stoichiometric ratio (metal:ligand). Tentative structures of the complexes were proposed based on elemental analysis, molar conductance, magnetic moments, thermogravimetric analysis, and spectral (infrared, electronic, and 1 H NMR) data. The particle size and morphological investigation were checked on the bases of scanning electron microscopy, transmission electron microscopy, and X-ray powder diffraction analyses. All the Mg 2+ , Ca 2+ , Cr 3+ , Zn 2+ , Cu 2+ , and Se 4+ complexes were found to be six-coordinated, wherein the STG ligands act as bidentate chelating agents. This study demonstrates that pancreatic tissues are affected by the induction of experimental diabetes mellitus and clarifies the potential of the synthesized STG complexes, which was found to more significantly improve insulin secretion and the pancreatic and glycometabolic complications of diabetic rats than STG alone.

Keywords: sitagliptin; complexes; spectroscopic; morphology; STZ; diabetes (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/15/8030/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/15/8030/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:15:p:8030-:d:604120

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().