Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Anatoly V. Skalny, Philippe Yu Kopylov, Monica M. B. Paoliello, Jung-Su Chang, Michael Aschner, Igor P. Bobrovnitsky, Jane C.-J. Chao, Jan Aaseth, Sergei N. Chebotarev and Alexey A. Tinkov
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Anatoly V. Skalny: World-Class Research Center “Digital Biodesign and Personalized Healthcare”, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
Philippe Yu Kopylov: World-Class Research Center “Digital Biodesign and Personalized Healthcare”, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
Monica M. B. Paoliello: Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY 10461, USA
Jung-Su Chang: College of Nutrition, Taipei Medical University, Taipei 110, Taiwan
Michael Aschner: Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY 10461, USA
Igor P. Bobrovnitsky: Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
Jane C.-J. Chao: College of Nutrition, Taipei Medical University, Taipei 110, Taiwan
Jan Aaseth: College of Public Health, Taipei Medical University, Taipei 110, Taiwan
Sergei N. Chebotarev: Department of Bioelementology, KG Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia
Alexey A. Tinkov: College of Public Health, Taipei Medical University, Taipei 110, Taiwan

IJERPH, 2021, vol. 18, issue 15, 1-11

Abstract: The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into normal weight control ( n = 123) and obese groups ( n = 140). Patients suffering from CHD were divided into normal weight ( n = 180) and obese CHD subjects ( n = 240). Hair Al, As, Cd, Hg, Ni, and Pb levels were evaluated using inductively-coupled plasma mass-spectrometry. The data demonstrate that hair Al and Hg levels were higher in obese subjects as compared to normal weight controls. Normal weight CHD patients were characterized by significantly higher hair Al, As, Cd, and Pb levels when compared to healthy subjects. The highest hair Al, As, and Pb levels were observed in obese CHD patients, significantly exceeding the respective values in other groups. Factorial analysis revealed significant influence of factorial interaction (CHD*obesity) only for hair Pb content. Given the role of obesity as a risk factor for CHD, it is proposed that increased toxic metal accumulation in obesity may promote further development of cardiovascular diseases.

Keywords: obesity; coronary heart disease; ischemic heart disease; lead; toxicity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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