A Retrospective Cohort Study of Oral Leukoplakia in Female Patients—Analysis of Risk Factors Related to Treatment Outcomes

Shih-Wei Yang, Yun-Shien Lee, Pei-Wen Wu, Liang-Che Chang and Cheng-Cheng Hwang
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Shih-Wei Yang: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung 204, Taiwan
Yun-Shien Lee: Department of Biotechnology, Ming Chuan University, Taoyuan 333, Taiwan
Pei-Wen Wu: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung 204, Taiwan
Liang-Che Chang: College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Cheng-Cheng Hwang: College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

IJERPH, 2021, vol. 18, issue 16, 1-17

Abstract: Background: The aim of this study was to make a comparison of clinicopathological characteristics of oral leukoplakia between male and female patients following carbon dioxide laser excision for oral leukoplakia and analyze the factors associated with the treatment outcomes in female patients. Methods: Medical records of patients with oral leukoplakia receiving laser surgery from 2002 to 2020 were retrospectively reviewed and analyzed statistically. Results: A total of 485 patients were enrolled, including 412 male (84.95%) and 73 female (15.05%). Regarding the locations, the predilection site of oral leukoplakia in male patients was buccal mucosa ( p = 0.0001) and that for women patients was tongue ( p = 0.033). The differences of recurrence and malignant transformation between both sexes were not significant ( p > 0.05). Among female patients, area of oral leukoplakia was the risk factor related to recurrence ( p < 0.05). Clinical morphology and postoperative recurrence were the risk factors related to malignant transformation ( p < 0.05). Conclusions: In comparison with male patients, there was no significant difference of the postoperative recurrence and malignant transformation of oral leukoplakia in female patients. Among the female patients, clinicians should pay more attention to large-sized and non-homogeneous leukoplakia, and postoperative recurrent lesions.

Keywords: female; leukoplakia; transformation; squamous cell carcinoma (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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