Association of Family History and Life Habits in the Development of Colorectal Cancer: A Matched Case-Control Study in Mexico

María del Pilar Ramírez-Díaz, María T. Alvarez-Bañuelos, Martha S. Robaina-Castellanos, Pedro P. Castro-Enríquez and Raúl E. Guzmán-García
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María del Pilar Ramírez-Díaz: Facultad de Nutrición, Universidad del Istmo, Juchitán 70102, Oaxaca, Mexico
María T. Alvarez-Bañuelos: Instituto de Salud Pública, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico
Martha S. Robaina-Castellanos: Instituto Nacional de Oncología y Radiobiología, La Habana 10400, Cuba
Pedro P. Castro-Enríquez: Instituto de Salud Pública, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico
Raúl E. Guzmán-García: Centro Estatal de Cancerología “Dr. Miguel Dorantes Mesa”, Xalapa 91130, Veracruz, Mexico

IJERPH, 2021, vol. 18, issue 16, 1-11

Abstract: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and, as such, is important for public health. The increased incidence of this neoplasm is attributed to non-modifiable controls such as family history and modifiable variable behavioral risk factors involved in lifestyle like diets in Mexico. The presence of these factors is unknown. Therefore, the aim of this study was to evaluate family history and lifestyle factors associated with developing colorectal cancer in a Mexican population. Descriptive statistics and multivariate logistic regression were used to estimate the adjusted odds ratios (OR), as well as the 95% confidence intervals (CI). In this paper, significant differences were demonstrated between cases and controls. A family history of cancer (FHC) increased the probability of CRC [OR = 3.19 (95% CI: 1.81–5.60)]. The area of urban residence was found to be a protective factor compared to the rural area. This was also the case for frequent consumption of fruits [OR = 0.49 (95% CI: 0.28–0.88)], the frequent consumption of beef [OR = 2.95 (95% CI: 1.05–8.26)], pork [OR = 3.26 (95% CI: 1.34–7.90)], and region-typical fried food [OR = 2.79 (95% CI (1.32–5.89)]. These results provide additional evidence supporting the association of some CRC risk factors with family history of cancer, low fruit consumption, high consumption of red meat, and fried foods typical of the region of México. It is important to establish intervention methods, as well as genetic counseling to relatives of patients with CRC.

Keywords: colorectal cancer; epidemiology; case-control; family history; dietary (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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