Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers

Tatsuya Yoshihara, Masayoshi Zaitsu, Kazuya Ito, Ryuzo Hanada, Eunhee Chung, Rie Yazawa, Yukikuni Sakata, Koki Furusho, Hiroshi Tsukikawa, Takeshi Chiyoda, Shunji Matsuki and Shin Irie
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Tatsuya Yoshihara: SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
Masayoshi Zaitsu: Department of Public Health, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan
Kazuya Ito: SOUSEIKAI Clinical Epidemiological Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
Ryuzo Hanada: SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan
Eunhee Chung: SOUSEIKAI Global Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
Rie Yazawa: SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan
Yukikuni Sakata: SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan
Koki Furusho: SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
Hiroshi Tsukikawa: SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
Takeshi Chiyoda: SOUSEIKAI Sumida Hospital, 1-29-1, Honjo, Sumida-ku, Tokyo 130-0004, Japan
Shunji Matsuki: SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan
Shin Irie: SOUSEIKAI Fukuoka Mirai Hospital Clinical Research Center, Kashiiteriha 3-5-1, Higashi-ku, Fukuoka 813-0017, Japan

IJERPH, 2021, vol. 18, issue 16, 1-7

Abstract: The concentration of cerebrospinal fluid total protein (CSF-TP) is important for the diagnosis of neurological emergencies. Recently, some Western studies have shown that the current upper reference limit of CSF-TP is quite low for older patients. However, little is reported about the concentration of CSF-TP in the older Asian population. In this study, we retrospectively analyzed the CSF-TP concentrations in healthy older Japanese volunteers. CSF samples in 69 healthy Japanese volunteers (age range: 55–73 years) were collected by lumbar puncture, and the data of CSF were retrospectively analyzed. The mean (standard deviation) CSF-TP was 41.7 (12.3) mg/dL. The older group (?65 years old) had higher CSF-TP concentration than the younger group (55–64 years old). The 2.5th percentile and 97.5th percentile of CSF-TP were estimated as 22.5 and 73.2 mg/dL, respectively, which were higher than the current reference range in Japan (10–40 mg/dL). Conclusions: The reference interval of CSF-TP in the older population should be reconsidered for the precise diagnosis of neurological emergencies.

Keywords: cerebrospinal fluid; total protein; reference interval; older population; Japanese healthy volunteer (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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