Association between Statin Use and Meniere’s Disease: Results from a National Health Screening Cohort

So Young Kim, Dae Myoung Yoo, Chanyang Min and Hyo Geun Choi
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So Young Kim: Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea
Dae Myoung Yoo: Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
Chanyang Min: Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
Hyo Geun Choi: Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea

IJERPH, 2021, vol. 18, issue 16, 1-10

Abstract: The protective effects of statins against inner ear diseases have been suggested. This study investigated the relationship between previous statin use and the occurrence of Meniere’s disease (MD). Participants ?40 years old in the Korean National Health Insurance Service-Health Screening Cohort 2002–2015 were enrolled. A total of 7734 MD participants were matched with 38,670 comparison participants. The dates of statin prescriptions for the 2 years before the onset of MD were examined. A conditional logistic regression analysis was performed to estimate the odds ratios (ORs) of statin use for MD. Regarding the different types of statins, lipophilic statins, but not hydrophilic statins, were associated with lower odds of MD in the <65 year-old group (adjusted OR = 0.81, 95% CI = 0.68–0.97, p = 0.023). Prior statin use did not show association with MD in the adult population. Regarding the different types of statins, lipophilic statin use was related to a lower rate of MD in a middle-aged population.

Keywords: Meniere’s disease; hydroxymethylglutaryl-CoA reductase inhibitors; cohort studies; case-control studies (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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