Genetic Polymorphism of Delta Aminolevulinic Acid Dehydratase ( ALAD ) Gene and Symptoms of Chronic Mercury Exposure in Munduruku Indigenous Children within the Brazilian Amazon

Jamila Alessandra Perini, Mayara Calixto Silva, Ana Claudia Santiago de Vasconcellos, Paulo Victor Sousa Viana, Marcelo Oliveira Lima, Iracina Maura Jesus, Joseph William Kempton, Rogério Adas Ayres Oliveira, Sandra Souza Hacon and Paulo Cesar Basta
Additional contact information
Jamila Alessandra Perini: Laboratório de Pesquisa de Ciências Farmacêuticas (LAPESF), Centro Universitário Estadual da Zona Oeste (UEZO), Av. Manuel Caldeira de Alvarenga, 1.203, Rio de Janeiro 23070-200, RJ, Brazil
Mayara Calixto Silva: Laboratório de Pesquisa de Ciências Farmacêuticas (LAPESF), Centro Universitário Estadual da Zona Oeste (UEZO), Av. Manuel Caldeira de Alvarenga, 1.203, Rio de Janeiro 23070-200, RJ, Brazil
Ana Claudia Santiago de Vasconcellos: Laboratório de Educação Profissional em Vigilância em Saúde, Escola Politécnica de Saúde Joaquim Venâncio, Fundação Oswaldo Cruz (EPSJV/Fiocruz), Av. Brasil, 4365-Manguinhos, Rio de Janeiro 21040-900, RJ, Brazil
Paulo Victor Sousa Viana: Centro de Referência Professor Hélio Fraga, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz (CRPHF/ENSP/Fiocruz), Estrada de Curicica, 2000-Curicica, Rio de Janeiro 22780-195, RJ, Brazil
Marcelo Oliveira Lima: Seção de Meio Ambiente, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde (SEAMB/IEC/SVS/MS), Rodovia BR-316 km 7 s/n-Levilândia, Ananindeua 67030-000, PA, Brazil
Iracina Maura Jesus: Seção de Meio Ambiente, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde (SEAMB/IEC/SVS/MS), Rodovia BR-316 km 7 s/n-Levilândia, Ananindeua 67030-000, PA, Brazil
Joseph William Kempton: Faculty of Medicine, Imperial College London, Medical School Building, St Mary’s Hospital, Norfolk Place, London W2 1PG, UK
Rogério Adas Ayres Oliveira: Faculdade de Medicina, Universidade de São Paulo—USP, São Paulo 01246-903, SP, Brazil
Sandra Souza Hacon: Departamento de Endemias Samuel Pessoa, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz (ENSP/Fiocruz), Rua Leopoldo Bulhões, 1480-Manguinhos, Rio de Janeiro 21041-210, RJ, Brazil
Paulo Cesar Basta: Departamento de Endemias Samuel Pessoa, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz (ENSP/Fiocruz), Rua Leopoldo Bulhões, 1480-Manguinhos, Rio de Janeiro 21041-210, RJ, Brazil

IJERPH, 2021, vol. 18, issue 16, 1-12

Abstract: Genetic polymorphisms involved in mercury toxicokinetics and toxicodynamics may be associated with severe mercury toxicity. This study aimed to investigate the impact of an ALAD polymorphism on chronic mercury exposure and the health situation of indigenous children from the Brazilian Amazon. One-hundred-and-three indigenous children (under 15 years old) were included and genotyped (rs1800435) using a TaqMan validated assay. The mean age was 6.6 ± 4.5 years old, 60% were female, 49% presented with anemia, and the mean hair mercury concentration was 7.0 ± 4.5 (1.4–23.9) µg/g, with 49% exceeding the reference limit (?6.0 µg/g). Only two children were heterozygous ALAD , while the others were all wild type. Minor allele frequency ( ALAD G ) and heterozygous genotype ( ALAD CG ) were 1% and 2%, respectively. The two children (12 and 14 years old) with the ALAD polymorphism had mercury levels above the average as well as had neurological symptoms related to chronic mercury exposure, such as visual field alterations, memory deficit, distal neuropathy, and toe amyotrophy. Both children also reported frequent consumption of fish in the diet, at least three times a week. In conclusion, our data confirm that an ALAD polymorphism can contribute to mercury half-life time, harmful effects, and neuropsychological disorders in indigenous children with chronic mercury exposure to gold mining activity.

Keywords: mercury exposure; ALAD; genetic polymorphism; neurotoxicity; environmental health; indigenous people (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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