Probabilistic Risk Assessment of Dietary Exposure to Chloramphenicol in Guangzhou, China

Yanyan Wang, Weiwei Zhang, Florence Mhungu, Yuhua Zhang, Yufei Liu, Yan Li, Xiaoyan Luo, Xinhong Pan, Jie Huang, Xianwu Zhong, Shaofang Song, Hailin Li, Yungang Liu and Kuncai Chen
Additional contact information
Yanyan Wang: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Weiwei Zhang: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Florence Mhungu: Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Yuhua Zhang: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Yufei Liu: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Yan Li: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Xiaoyan Luo: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Xinhong Pan: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Jie Huang: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Xianwu Zhong: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Shaofang Song: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Hailin Li: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China
Yungang Liu: Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Kuncai Chen: Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China

IJERPH, 2021, vol. 18, issue 16, 1-11

Abstract: Chloramphenicol has been used in veterinary medicine, where its residues can remain in food of animal origin, thus potentially causing adverse health effects. This facilitated the ban for its use in food-producing animals globally, but its residues have remained ubiquitous. In this study, food commodities possibly contaminated with chloramphenicol, including livestock meat, poultry, edible viscera, fish, shrimp and crab, molluscs, milk, and eggs, were collected from domestic retail shops in all the 11 districts of Guangzhou and tested for its residue. Probabilistic risk assessment model calculations for its dietary exposure, and the margin of exposure (displayed as mean values and 5th percentile to 95th percentile ranges) were performed by using @RISK software based on a Monte Carlo simulation with 10,000 iterations. The results indicated the detection of chloramphenicol in 248 out of 1454 samples (17.1%), which averaged to a level of 29.1 ?g/kg. The highest average value was observed in molluscs (148.2 ?g/kg, with the top value as 8196 ?g/kg); meanwhile, based on the dietary structure of a typical Cantonese, pond fish, pork, and poultry meat contributed most (about 80%) to the residents’ dietary exposure to chloramphenicol. The margin of exposure for dietary chloramphenicol exposure in Guangzhou residents was 2489, which was apparently below 5000 (the borderline for judging a health risk), particularly low in preschool children (2094, suggesting an increased risk). In conclusion, the study suggests that chloramphenicol exposure in Guangzhou residents is considerable, and its relevant health hazard, especially for preschool children, is worthy of further investigation.

Keywords: chloramphenicol; residue; dietary exposure; risk assessment; @RISK (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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