Biomonitoring of Phthalates, Bisphenols and Parabens in Children: Exposure, Predictors and Risk Assessment

Pablo Dualde, Nuria León, Yovana Sanchis, Francisca Corpas-Burgos, Sandra F. Fernández, Cristina S. Hernández, Guillermo Saez, Erika Pérez-Zafra, Antonio Mora-Herranz, Olga Pardo, Clara Coscollà, Antonio López, Vicent Yusà and on behalf of the BIOVAL Task Force
Additional contact information
Pablo Dualde: Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Nuria León: Public Health Laboratory of Valencia, Av. Cataluña, 21, 46020 Valencia, Spain
Yovana Sanchis: Public Health Laboratory of Valencia, Av. Cataluña, 21, 46020 Valencia, Spain
Francisca Corpas-Burgos: Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Sandra F. Fernández: Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Cristina S. Hernández: Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Guillermo Saez: Conselleria Sanitat, Universitary Hospital Doctor Peset, Av. Gaspar Aguilar, 90, 46017 Valencia, Spain
Erika Pérez-Zafra: Conselleria Sanitat, Universitary Hospital Doctor Peset, Av. Gaspar Aguilar, 90, 46017 Valencia, Spain
Antonio Mora-Herranz: Conselleria Sanitat, Universitary Hospital Doctor Peset, Av. Gaspar Aguilar, 90, 46017 Valencia, Spain
Olga Pardo: Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Clara Coscollà: Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Antonio López: Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
Vicent Yusà: Foundation for the Promotion of Health and Biomedical Research of the Valencian Region, FISABIO-Public Health, Av. Catalunya, 21, 46020 Valencia, Spain
on behalf of the BIOVAL Task Force: Membership of the BIOVAL Task Force is provided in the Acknowledgments.

IJERPH, 2021, vol. 18, issue 17, 1-21

Abstract: Exposure to emerging contaminants, such as phthalates, bisphenols and parabens in children has been associated with possible neurodevelopment and endocrine alterations. In the present study, the biomonitoring of biomarkers in children (5–12 years old) from the Valencia Region (Spain) have been implemented using urines from the BIOVAL program. More than 75% of the children studied ( n = 562) were internally exposed (>LOQ) to bisphenols and parabens, and the whole population assessed ( n = 557) were exposed to at least one phthalate. The geometric means (GM) of the concentrations of bisphenol A, methyl paraben and propyl paraben were 0.9, 1.4 and 0.39 ng/mL, respectively. Regarding phthalates, monoethyl phthalate GM was 55.0 ng/mL and diethyl hexyl phthalate (as the sum of five metabolites) GM was 60.6 ng/mL. Despite the studied population being widely exposed, the detection frequencies and concentrations were in general lower than in previous studies involving children in Spain and in other countries in recent years. Furthermore, the risk assessment study concluded that the internal exposure to phthalates, bisphenols and parabens is lower than the guidance values established, and, therefore, a health risk derived from the exposure to these compounds in the studied population is not expected.

Keywords: biomonitoring; phthalates; bisphenols; parabens; urine; risk assessment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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