Relationships of Dietary Habits and Physical Activity Status with Non-Alcoholic Fatty Liver Disease Featuring Advanced Fibrosis

Yoshito Yabe, Taeho Kim, Sechang Oh, Takashi Shida, Natsumi Oshida, Naoyuki Hasegawa, Kosuke Okada, Noriko Someya, Yuji Mizokami and Junichi Shoda
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Yoshito Yabe: Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Taeho Kim: The Center for Sports Medicine and Health Sciences, Tsukuba University Hospital, Tsukuba 305-8576, Japan
Sechang Oh: Division of Radiology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Takashi Shida: Medical Technology and Science, International University of Health and Welfare, Narita 286-8686, Japan
Natsumi Oshida: Division of Laboratory Medicine, Tsukuba University Hospital, Tsukuba 305-8576, Japan
Naoyuki Hasegawa: Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Kosuke Okada: Tsukuba Preventive Medicine Research Center, University of Tsukuba Hospital, Tsukuba 305-8576, Japan
Noriko Someya: The Center for Sports Medicine and Health Sciences, Tsukuba University Hospital, Tsukuba 305-8576, Japan
Yuji Mizokami: Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Junichi Shoda: Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan

IJERPH, 2021, vol. 18, issue 17, 1-14

Abstract: (1) Aim: Hepatic fibrosis is a prognostic factor for disease progression in non-alcoholic fatty liver disease (NAFLD). We aimed to determine the relationships between diet, physical activity, and the progression of liver fibrosis. (2) Methods: The 349 participants were categorized by their FibroScan-aspartate aminotransferase score, and they completed a questionnaire regarding their diet and physical activity. (3) Results: There were 233 patients in the negative-on-screening group, 78 in the gray zone group, and 38 in the positive-on-screening group. The frequencies of consumption of soybeans and soybean products and of light-colored vegetables were lower in the positive group; whereas the frequencies of consumption of snack food and fried sweets, jelly and pudding, fried food, and butter, lard, and beef tallow were higher. The odds ratios for the fibrosis progression in patients who consumed fried food ?4 times/week was 2.21. The positive group also showed lower physical activity level (PAL) and exercise (Ex, metabolic equivalents for tasks (METs)/hour/week). The patients who undertook Ex at >7.5 had an odds ratio of 0.21 for the fibrosis progression. (4) Conclusion: High consumption of fried food and low Ex are risk factors for the fibrosis progression in NAFLD.

Keywords: non-alcoholic fatty liver disease; liver fibrosis; dietary habits; physical activity; Fibroscan-AST score (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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