The Association of Renal Function and Plasma Metals Modified by EGFR and TNF-? Gene Polymorphisms in Metal Industrial Workers and General Population

Tzu-Hua Chen, Joh-Jong Huang, Hsiang-Ying Lee, Wei-Shyang Kung, Kuei-Hau Luo, Jia-Yi Lu and Hung-Yi Chuang
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Tzu-Hua Chen: Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Joh-Jong Huang: Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
Hsiang-Ying Lee: Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
Wei-Shyang Kung: Department of Pediatrics, Chien Shin Hospital, Kaohsiung 80143, Taiwan
Kuei-Hau Luo: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Jia-Yi Lu: Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Hung-Yi Chuang: Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

IJERPH, 2021, vol. 18, issue 17, 1-13

Abstract: Exposure to metals may be associated with renal function impairment, but the effect modified by genetic polymorphisms was not considered in most studies. Epidermal growth factor receptor (EGFR) and tumor necrotic factor-? (TNF-?) play important roles in renal hemodynamics, and they have been reported to be associated with some renal diseases. The aim of our research is to explore whether genetic variations in EGFR and TNF-? have influence on renal function under exposure to various metals. This cross-sectional study consisted of 376 metal industrial workers, 396 participants of Taiwan Biobank, and 231 volunteers of health examinations. We identified 23 single nucleotide polymorphisms (SNPs) on the EGFR gene and 6 SNPs on the TNF-? gene, and we also measured their plasma concentration of cobalt, copper, zinc, selenium, arsenic, and lead. Multiple regression analysis was applied to investigate the association between various SNPs, metals, and renal function. Our results revealed some protective and susceptible genotypes under occupational or environmental exposure to metals. The individuals carrying EGFR rs2280653 GG might have declined renal function under excessive exposure to selenium, and those with EGFR rs3823585 CC, rs12671550 CC, and rs4947986 GG genotypes might be susceptible to lead nephrotoxicity. We suggest the high-risk population to prevent renal diseases.

Keywords: health risk assessment; toxic metals; EGFR; TNF-?; single nucleotide polymorphism (SNP); renal function; environmental strategy; Taiwan Biobank (TWB) (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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