How Much Does HIV Positivity Affect the Presence of Oral HPV? A Molecular Epidemiology Survey

Giuseppa Visalli, Angela Di Pietro, Monica Currò, Marianna Pruiti Ciarello, Flavia D’Andrea, Giuseppe Nunnari, Giovanni Francesco Pellicanò and Alessio Facciolà
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Giuseppa Visalli: Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy
Angela Di Pietro: Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy
Monica Currò: Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy
Marianna Pruiti Ciarello: Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy
Flavia D’Andrea: Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, 98122 Messina, Italy
Giuseppe Nunnari: Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, 98122 Messina, Italy
Giovanni Francesco Pellicanò: Department of Human Pathology of the Adult and the Developmental Age “G. Barresi”, Unit of Infectious Diseases, University of Messina, 98122 Messina, Italy
Alessio Facciolà: Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy

IJERPH, 2021, vol. 18, issue 17, 1-12

Abstract: HIV-positive people showed a high oral prevalence of HPV-DNA and have a greater incidence of head and neck carcinomas compared to general population. We performed a molecular survey evaluating the presence of HPV-DNA in saliva of HIV-positive and HIV-negative subjects in order to quantify the risk represented by HIV-positivity. The sample was made up by 102 subjects: 40 HIV-positive, 32 HIV-negative with sexual risk behaviors (SRB) and 30 HIV-negative without risk factors. DNA was extracted from cellular pellets and HPV detection and genotyping were performed by PCR assays. In the HIV-positive group (of which 58.3% declared SRB) 33.33% of the sample were HPV-positive (33.33% to high-risk genotypes, 25.0% to low-risk genotypes and 41.66% to other genotypes). In the HIV-negative SRB group, HPV-positive subjects were 37.04% (60.0% to high risk genotypes, 20.0% to low risk genotypes, and 20.0% to other genotypes). Finally, in the control group, the HPV-positive subjects were 7.14% (50% to high-risk genotypes and 50% to low-risk genotypes). In the HIV group, concerning the HPV positivity, there was no significant difference between subjects with and without SRBs. In summary, we found a high oral HPV-DNA detection in HIV+ group, showing a strong relationship between HIV and HPV.

Keywords: HIV; sexual risk behaviors; oral HPV (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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