Estrogen and Progesterone Receptor Immunoexpression in Fallopian Tubes among Postmenopausal Women Based on Time since the Last Menstrual Period

Agnieszka Brodowska, Marta Grabowska, Katarzyna Bittel, Sylwester Ciećwież, Jacek Brodowski, Małgorzata Szczuko, Iwona Szydłowska and Małgorzata Piasecka
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Agnieszka Brodowska: Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Unii Lubelskiej 1, 71-256 Szczecin, Poland
Marta Grabowska: Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland
Katarzyna Bittel: Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Unii Lubelskiej 1, 71-256 Szczecin, Poland
Sylwester Ciećwież: Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Unii Lubelskiej 1, 71-256 Szczecin, Poland
Jacek Brodowski: Department of Primary Healthcare, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland
Małgorzata Szczuko: Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, Poland
Iwona Szydłowska: Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Unii Lubelskiej 1, 71-256 Szczecin, Poland
Małgorzata Piasecka: Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland

IJERPH, 2021, vol. 18, issue 17, 1-12

Abstract: Existing data on the expression of estrogen receptor (ER?) and progesterone receptor (PR) in fallopian tubes in postmenopausal women are mostly inconclusive. Therefore, we assessed ER? and PR immunoexpression in the oviducts of these women. One hundred postmenopausal women were divided into three groups based on time elapsed since the last menstrual period: (A) 1–5 years, (B) 6–10 years, and (C) ?11 years. In all groups, both in the glandular epithelium and stroma of the ampulla and isthmus of the oviduct, immunolocalization of ER? and PR were noted. The glandular epithelium of the ampulla showed a higher percentage of PR-positive cells than the isthmus in each group. Regarding ER?, there were no significant differences. In the glandular epithelium in both the ampulla and isthmus, the percentage of ER?- and PR-positive cells was significantly higher than that in the stroma in each study group and higher in the A group than in the C group. In conclusion, in postmenopausal women, time elapsed since the last menstrual period in the fallopian tubes was positively correlated with the following: (1) the epithelium showed vacuolation of cytoplasm with greater frequency, (2) the proportion of ciliated cells decreased, and (3) the percentage of ER?- and PR-positive cells also decreased. The obtained results indicate a significant decrease in ER? and PR expression depending on the time that has elapsed since the last menstruation, which is undoubtedly related to the loss of the reproductive function of the patients.

Keywords: fallopian tube; estrogen receptor; progesterone receptor; menopause (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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