Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction

Md. Khalequzzaman Sarker, Selim Reza Tony, Abu Eabrahim Siddique, Md. Rezaul Karim, Nazmul Haque, Zohurul Islam, Md. Shofikul Islam, Moriom Khatun, Jahidul Islam, Shakhawoat Hossain, Zahangir Alam Saud, Hideki Miyataka, Daigo Sumi, Aaron Barchowsky, Seiichiro Himeno and Khaled Hossain
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Md. Khalequzzaman Sarker: Institute of Biological Sciences, University of Rajshahi, Rajshahi 6205, Bangladesh
Selim Reza Tony: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
Abu Eabrahim Siddique: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
Md. Rezaul Karim: Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, Bangladesh
Nazmul Haque: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
Zohurul Islam: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
Md. Shofikul Islam: Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, Bangladesh
Moriom Khatun: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
Jahidul Islam: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
Shakhawoat Hossain: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
Zahangir Alam Saud: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
Hideki Miyataka: Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan
Daigo Sumi: Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan
Aaron Barchowsky: Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Seiichiro Himeno: Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan
Khaled Hossain: Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh

IJERPH, 2021, vol. 18, issue 18, 1-18

Abstract: Skeletal muscle mass reduction has been implicated in insulin resistance (IR) that promotes cardiometabolic diseases. We have previously reported that arsenic exposure increases IR concomitantly with the reduction of skeletal muscle mass among individuals exposed to arsenic. The arsenic methylation capacity is linked to the susceptibility to some arsenic exposure-related diseases. However, it remains unknown whether the arsenic methylation capacity affects the arsenic-induced reduction of muscle mass and elevation of IR. Therefore, this study examined the associations between the arsenic methylation status and skeletal muscle mass measures with regard to IR by recruiting 437 participants from low- and high-arsenic exposure areas in Bangladesh. The subjects’ skeletal muscle mass was estimated by their lean body mass (LBM) and serum creatinine levels. Subjects’ drinking water arsenic concentrations were positively associated with total urinary arsenic concentrations and the percentages of MMA, as well as inversely associated with the percentages of DMA and the secondary methylation index (SMI). Subjects’ LBM and serum creatinine levels were positively associated with the percentage of DMA and SMI, as well as inversely associated with the percentage of MMA. HOMA-IR showed an inverse association with SMI, with a confounding effect of sex. Our results suggest that reduced secondary methylation capacity is involved in the arsenic-induced skeletal muscle loss that may be implicated in arsenic-induced IR and cardiometabolic diseases.

Keywords: arsenic; metabolites; muscle mass; insulin resistance; diabetes; cardiometabolic disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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