Oxidative Stress and Inflammation, MicroRNA, and Hemoglobin Variations after Administration of Oxygen at Different Pressures and Concentrations: A Randomized Trial

Gerardo Bosco, Matteo Paganini, Tommaso Antonio Giacon, Alberto Oppio, Alessandra Vezzoli, Cinzia Dellanoce, Tatiana Moro, Antonio Paoli, Federica Zanotti, Barbara Zavan, Costantino Balestra and Simona Mrakic-Sposta
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Gerardo Bosco: Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
Matteo Paganini: Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
Tommaso Antonio Giacon: Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
Alberto Oppio: Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
Alessandra Vezzoli: Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy
Cinzia Dellanoce: Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy
Tatiana Moro: Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
Antonio Paoli: Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy
Federica Zanotti: Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy
Barbara Zavan: Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy
Costantino Balestra: Environmental, Occupational, Ageing (Integrative) Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), 1180 Brussels, Belgium
Simona Mrakic-Sposta: Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy

IJERPH, 2021, vol. 18, issue 18, 1-17

Abstract: Exercise generates reactive oxygen species (ROS), creating a redox imbalance towards oxidation when inadequately intense. Normobaric and hyperbaric oxygen (HBO) breathed while not exercising induces antioxidant enzymes expression, but literature is still poor. Twenty-two athletes were assigned to five groups: controls; 30%, or 50% O 2 ; 100% O 2 (HBO) at 1.5 or 2.5 atmosphere absolute (ATA). Twenty treatments were administered on non-training days. Biological samples were collected at T0 (baseline), T1 (end of treatments), and T2 (1 month after) to assess ROS, antioxidant capacity (TAC), lipid peroxidation, redox (amino-thiols) and inflammatory (IL-6, 10, TNF-?) status, renal function (i.e., neopterin), miRNA, and hemoglobin. At T1, O 2 mixtures and HBO induced an increase of ROS, lipid peroxidation and decreased TAC, counterbalanced at T2. Furthermore, 50% O 2 and HBO treatments determined a reduced state in T2. Neopterin concentration increased at T1 breathing 50% O 2 and HBO at 2.5 ATA. The results suggest that 50% O 2 treatment determined a reduced state in T2; HBO at 1.5 and 2.5 ATA similarly induced protective mechanisms against ROS, despite the latter could expose the body to higher ROS levels and neopterin concentrations. HBO resulted in increased Hb levels and contributed to immunomodulation by regulating interleukin and miRNA expression.

Keywords: oxygen; redox state; hyperbaric oxygen therapy; hyperoxia (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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