Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Yiming Pang, Jianjun Jiang, Kexin Li, Lailai Yan, Yanqiu Feng, Junli Wang, Xiaolu Cao, Zhiwen Li and Bin Wang
Additional contact information
Yiming Pang: Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Institute of Reproductive and Child Health, Peking University, Beijing 100191, China
Jianjun Jiang: Department of Toxicology, School of Public Health, Peking University, Beijing 100191, China
Kexin Li: Institute of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, China
Lailai Yan: Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, China
Yanqiu Feng: Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Institute of Reproductive and Child Health, Peking University, Beijing 100191, China
Junli Wang: Basic Clinical Laboratory Teaching and Research Department, School of Medical Laboratory, Youjiang Medical University for Nationalities, Baise 533000, China
Xiaolu Cao: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Environmental Health and Occupational Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430081, China
Zhiwen Li: Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Institute of Reproductive and Child Health, Peking University, Beijing 100191, China
Bin Wang: Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Institute of Reproductive and Child Health, Peking University, Beijing 100191, China

IJERPH, 2021, vol. 18, issue 18, 1-12

Abstract: Solid fuel combustion is an important source of the release of rare earth elements ( REEs ) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pressure change. A total of 24 rats were administered with 14 REE chlorides at four doses (six rats per group). Fur samples were collected both before and after administration. Blood samples were collected after 12 weeks of REE intake. The REE concentrations in rat fur and blood samples were measured by inductively coupled plasma mass spectrometry. For each week, blood pressure, as well as heart rate and pulse pressure, were measured. The linear mixed-effect model was used to analyze the relationship between REE administration dose and blood pressure change. We found that the REE concentration in fur, but not blood, samples exhibited significant dose–response relationships with administration dose. It suggested that hair samples are a more efficient matrix for indicating the exposure level of a population to REEs than blood samples. However, there was no dose–response relationships between the administration dose and blood pressure change of rats, or with heart rate and pulse pressure for the 14 REEs . We also did not find a dose–response relationship between REE administration levels and plasma concentration of 8-hydroxy-2’-deoxyguanosine, as an important DNA oxidative stress damage biomarker. In conclusion, hair samples are more suitable as a sample type to reliably assess exposure to REEs than blood samples, and REEs did not have a direct adverse effect on blood pressure in our rat model.

Keywords: rare earth elements; hair; blood pressure; biomarker; oxidative stress (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/18/9836/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/18/9836/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:18:p:9836-:d:638530

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().