Method for Determining Regional Reference Values of Metal Content in Biological Substrates and Their Intake into the Body via Drinking Water

Yulia Tunakova, Artur Shagidullin, Vsevolod Valiev, Svetlana Novikova and Rashat Faizullin
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Yulia Tunakova: Department of General Chemistry and Ecology, Kazan National Research Technical University named after A. N. Tupolev (KNRTU–KAI), 420126 Kazan, Russia
Artur Shagidullin: Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, 420087 Kazan, Russia
Vsevolod Valiev: Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, 420087 Kazan, Russia
Svetlana Novikova: Department of General Chemistry and Ecology, Kazan National Research Technical University named after A. N. Tupolev (KNRTU–KAI), 420126 Kazan, Russia
Rashat Faizullin: Institute of Fundamental Medicine and Biology, Kazan Federal University, 420012 Kazan, Russia

IJERPH, 2021, vol. 18, issue 18, 1-9

Abstract: Natural and manmade flows of matter form complex metal associations in the body of residents living in certain territories, which leads to functional disorders in their bodies and the depletion of adaptive reserves. It is possible to assess the distribution of metals in the body only taking into account its biogeochemical localization. The question arises about the methodological approach to the determination of regional reference values of the concentrations of metals in biosubstrates of residents of different territories, to which this study was devoted. A designed and trained neural network was used, reflecting the relationship between the concentrations of metals in consumed drinking water and biosubstrates of the body, taking into account the physiological characteristics of the tested group of children and adolescents, based on the regional reference values obtained. Neural network regression methods allowed the calculation of nonlinear dependences of indicators of the state of the internal environment of an organism with external factors, and localized reference values determined in such calculations the indicators of the base state, being guided by the intensity of external factors, which should be assessed. The results of this study are intended for patient-oriented diagnosis and the treatment of eco-conditioned microelementosis in individual locations.

Keywords: metals; drinking water; biosubstrates; reference values; neural network technologies; intake into the body (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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