Health-Related Quality of Life (HRQoL) Outcomes Following Injury in Childhood and Adolescence Using EuroQol (EQ-5D) Responses with Pooled Longitudinal Data

Joanna F. Dipnall, Frederick P. Rivara, Ronan A. Lyons, Shanthi Ameratunga, Mariana Brussoni, Fiona E. Lecky, Clare Bradley, Ben Beck, Jane Lyons, Amy Schneeberg, James E. Harrison and Belinda J. Gabbe
Additional contact information
Joanna F. Dipnall: School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia
Frederick P. Rivara: Departments of Pediatrics and Epidemiology, Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA 98195, USA
Ronan A. Lyons: School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia
Shanthi Ameratunga: School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia
Mariana Brussoni: Department of Pediatrics, School of Population and Public Health, University of British Columbia, Vancouver, BC V6H 3V4, Canada
Fiona E. Lecky: Centre for Urgent and Emergency Care Research, School of Health and Related Research, University of Sheffield, Sheffield S10 2TN, UK
Clare Bradley: South Australian Health and Medical Research Institute, Adelaide 5001, Australia
Ben Beck: School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia
Jane Lyons: Health Data Research UK, Swansea University, Swansea SA2 8PP, UK
Amy Schneeberg: British Columbia Injury Research and Prevention Unit, British Columbia Children’s Hospital Research Institute, Vancouver, BC V6H 3V4, Canada
James E. Harrison: College of Medicine and Public Health, Flinders University, Bedford Park 5042, Australia
Belinda J. Gabbe: School of Public Health and Preventive Medicine, Monash University, Melbourne 3004, Australia

IJERPH, 2021, vol. 18, issue 19, 1-19

Abstract: Background: Injury is a leading contributor to the global disease burden in children, affecting their health-related quality of life (HRQoL)—yet valid estimates of burden are absent. Methods: This study pooled longitudinal data from five cohort studies of pediatric injury survivors (5–17 years) at baseline, 1-, 4-, 6-, 12-, and 24- months ( n = 2334). HRQoL post-injury was measured using the 3-level EQ-5D utility score (EQ-5D) and five health states (mobility, self-care, activity, pain, anxiety and depression (anxiety)). Results: Mean EQ-5D post-injury did not return to baseline level (0.95) by 24 months (0.88) and was lower for females over time (?0.04, 95%CI ?0.05, ?0.02). A decreased adjusted risk ratio over time (ARR) was observed for intentional injuries (pain: 0.85, 95%CI 0.73,0.98; anxiety: 0.62, 95%CI 0.49,0.78); spinal cord injuries (mobility: 0.61, 95%CI 0.45,0.83), self-care: 0.76, 95%CI 0.63,0.91, activity: 0.64, 95%CI 0.47,0.88); moderate/severe traumatic brain injury (activity: 0.83, 95%CI 0.71,0.96). ARRs were also low for certain fractures, with various health states affected. Conclusions: HRQoL outcomes over time for children and adolescents post-injury differed across key demographic and injury related attributes. HRQoL did not reach levels consistent with full health by 24 months with recovery plateauing from 6 to 24 months. Tailored interventions are required to respond to the varying post-injury recovery trajectories in this population.

Keywords: health-related quality of life; health outcomes; disability; trauma; injury; EQ-5D; children; pediatric; adolescents (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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