Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters

Ting Zhu, Yuxiang Hu, Jooyeon Hwang, Dan Zhao, Libin Huang, Liang Qiao, Ankui Wei and Xin Xu
Additional contact information
Ting Zhu: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China
Yuxiang Hu: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China
Jooyeon Hwang: Department of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Dan Zhao: Department of Chemistry, Fudan University, Shanghai 200433, China
Libin Huang: Baoshan Fire and Rescue Division of Shanghai, Shanghai 201901, China
Liang Qiao: Department of Chemistry, Fudan University, Shanghai 200433, China
Ankui Wei: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China
Xin Xu: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China

IJERPH, 2021, vol. 18, issue 20, 1-16

Abstract: Firefighting rescues are high-hazard activities accompanied by uncertainty, urgency, and complexity. Knowledge of the metabolic characteristics during firefighting rescues is of great value. The purpose of this study was to explore the firefighting-induced physiological responses in greater depth. The urine samples of ten firefighters were collected before and after the simulated firefighting, and the proteins in urine samples were identified by the liquid chromatography–mass spectroscopy. Blood lactate and heart rate were measured. There were 360 proteins up-regulated and 265 proteins downregulated after this simulated firefighting. Changes in protein expression were significantly related to acute inflammatory responses, immune responses, complement activation, and oxidative stress. Beta-2-microglobulin (r = 0.76, p < 0.05) and von Willebrand factors (r = 0.81, p < 0.01) were positively correlated with heart rate during simulated firefighting, and carbonic anhydrase 1 (r = 0.67, p < 0.05) were positively correlated with blood lactate after simulated firefighting. These results illustrated that Beta-2-microglobulin, von Willebrand, and carbonic anhydrase 1 could be regarded as important indicators to evaluate exercise intensity for firefighters.

Keywords: firefighting; urine; proteomics; liquid chromatography–mass spectroscopy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/20/10618/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/20/10618/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:20:p:10618-:d:653238

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().