Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome

Jacopo Mariani, Simona Iodice, Laura Cantone, Giulia Solazzo, Paolo Marraccini, Emanuele Conforti, Pallav A. Bulsara, Maria Stella Lombardi, Robert P. Howlin, Valentina Bollati and Luca Ferrari
Additional contact information
Jacopo Mariani: EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Simona Iodice: EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Laura Cantone: EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Giulia Solazzo: EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Paolo Marraccini: Department of Preventive Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Emanuele Conforti: Department of Preventive Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Pallav A. Bulsara: GlaxoSmithKline Consumer Healthcare, Warren, NJ 07059, USA
Maria Stella Lombardi: GlaxoSmithKline Consumer Healthcare, CH-1260 Nyon, Switzerland
Robert P. Howlin: GlaxoSmithKline Consumer Healthcare, Weybridge KT13 0DE, UK
Valentina Bollati: EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Luca Ferrari: EPIGET LAB, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy

IJERPH, 2021, vol. 18, issue 20, 1-19

Abstract: Particulate matter (PM) exposure is linked to the worsening of respiratory conditions, including allergic rhinitis (AR), as it can trigger nasal and systemic inflammation. To unveil the underlying molecular mechanisms, we investigated the effects of PM exposure on the release of plasmatic extracellular vesicles (EV) and on the complex cross-talk between the host and the nasal microbiome. To this aim, we evaluated the effects of PM 10 and PM 2.5 exposures on both the bacteria-derived-EV portion (bEV) and the host-derived EVs (hEV), as well as on bacterial nasal microbiome (bNM) features in 26 AR patients and 24 matched healthy subjects (HS). In addition, we assessed the role exerted by the bNM as a modifier of PM effects on the complex EV signaling network in the paradigmatic context of AR. We observed that PM exposure differently affected EV release and bNM composition in HS compared to AR, thus potentially contributing to the molecular mechanisms underlying AR. The obtained results represent the first step towards the understanding of the complex signaling network linking external stimuli, bNM composition, and the immune risponse.

Keywords: allergic rhinitis; particulate matter exposure; extracellular vesicles; bacterial nasal microbiome (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/18/20/10689/pdf (application/pdf)
https://www.mdpi.com/1660-4601/18/20/10689/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:18:y:2021:i:20:p:10689-:d:654311

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().