Correlation between Severity of Fetal Growth Restriction and Oxidative Stress in Severe Small-for-Gestational-Age Infants

Mariko Ashina, Takumi Kido, Yuki Kyono, Asumi Yoshida, Shutaro Suga, Ruka Nakasone, Shinya Abe, Kenji Tanimura, Kandai Nozu and Kazumichi Fujioka
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Mariko Ashina: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Takumi Kido: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Yuki Kyono: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Asumi Yoshida: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Shutaro Suga: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Ruka Nakasone: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Shinya Abe: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Kenji Tanimura: Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Kandai Nozu: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
Kazumichi Fujioka: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan

IJERPH, 2021, vol. 18, issue 20, 1-8

Abstract: Severe small-for-gestational-age (sSGA) infants exhibit increased mortality and morbidity. Oxidative stress is suggested to be involved in intrauterine growth restriction. This retrospective study aimed to evaluate the oxidative stress level at birth in an sSGA population. Sera of 28 sSGA (sSGA group) and 31 non-sSGA (control group) infants, born at our hospital between March 2017 and March 2020, were evaluated. Oxidative stress (derivative of reactive oxidative metabolites: d-ROM level), biological antioxidant potential (BAP) level, and the ratio of d-ROM/BAP level (oxidative stress index: OSI) were measured. The sSGA group had a significantly lower birth weight (BW), BW z-score, head circumference, and height than the control group (all p < 0.05). No significant difference was noted in the BAP level; sSGA infants exhibited a significantly higher d-ROM level than control infants. sSGA infants showed a significantly increased OSI compared with control infants, and the BW z-score was inversely correlated with d-ROM levels and OSI in sSGA infants (R 2 = 0.300; p < 0.01 and R 2 = 0.319; p = 0.02, respectively) but not in controls. In conclusion, sSGA infants, including preterm infants, exhibited higher oxidative stress at birth. The severity of fetal growth restriction was significantly correlated with oxidative stress levels at birth in sSGA infants.

Keywords: small for gestational age; oxidative stress; fetal growth restriction; z-score (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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