Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Neeranuch Suwannarin, Tippawan Prapamontol, Tomohiko Isobe, Yukiko Nishihama, Ampica Mangklabruks, Tawiwan Pantasri, Somporn Chantara, Warangkana Naksen and Shoji F. Nakayama
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Neeranuch Suwannarin: Ph.D. Degree Program in Environmental Science, Environmental Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Tippawan Prapamontol: Environmental and Occupational Health Sciences and Non-Communicable Diseases Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
Tomohiko Isobe: Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan
Yukiko Nishihama: Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan
Ampica Mangklabruks: Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Tawiwan Pantasri: Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Somporn Chantara: Environmental Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Warangkana Naksen: Faculty of Public Health, Chiang Mai University, Chiang Mai 50200, Thailand
Shoji F. Nakayama: Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-8506, Japan

IJERPH, 2021, vol. 18, issue 20, 1-14

Abstract: Exposure to insecticides may result in various health problems. This study investigated the association between haematological parameters and exposure to a mixture of organophosphate (OP) and neonicotinoid (NEO) insecticides among male farmworkers in Fang district, Chiang Mai province, northern Thailand. Concentrations of urinary dialkylphosphates, non-specific metabolites of OPs, and NEOs and their metabolites and haematological parameters were measured in 143 male farmworkers. The Bayesian kernel machine regression model was employed to evaluate the associations. Exposure to a mixture of insecticides was significantly associated with the mean corpuscular haemoglobin concentration (MCHC) when the concentrations of all the compounds and their metabolites were at the 60th percentile or higher compared with the 50th percentile. Furthermore, exposure to clothianidin (CLO) showed a decreasing association with MCHC when all the other insecticides were at their mean concentrations. CLO was the most likely compound to reduce MCHC, and this was confirmed by sensitivity analysis. These findings suggest that exposure to NEO insecticides, especially CLO, affects the haematological status relating to haemoglobin parameters.

Keywords: organophosphates; dialkylphosphates; neonicotinoids; insecticides; metabolites; haematological parameters; farmworker; occupational health; environmental health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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