Pre-Exposure Prophylaxis (PrEP) Adherence Questionnaire: Psychometric Validation among Sexually Transmitted Infection Patients in China

Xiaoyue Yu, Chen Xu, Yang Ni, Ruijie Chang, Huwen Wang, Ruijie Gong, Ying Wang, Suping Wang and Yong Cai
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Xiaoyue Yu: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
Chen Xu: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
Yang Ni: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
Ruijie Chang: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
Huwen Wang: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
Ruijie Gong: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
Ying Wang: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
Suping Wang: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China
Yong Cai: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200003, China

IJERPH, 2021, vol. 18, issue 20, 1-12

Abstract: Background: Ensuring adherence guarantees the efficacy of pre-exposure prophylaxis (PrEP). Methods: We conducted a cross-sectional study among 816 sexually transmitted infection (STI) patients in Shanghai. The questionnaire included self-reported demographic characteristics, self-administered items on adherence to free oral PrEP, and PrEP uptake behavior measurement. We conducted item analysis, reliability analysis, validity analysis and receiver operating characteristic (ROC) curve analysis. Results: Not all items were considered acceptable in the item analysis. The questionnaire had a McDonald’s ? coefficient of 0.847. The scale-level content validity index (CVI) was 0.938 and the item-level CVI of each item ranged from 0.750 to 1. In exploratory factor analysis, we introduced a four-factor model accounting for 79.838% of the aggregate variance, which was validated in confirmatory factor analysis. Adding PrEP adherence questionnaire scores contributed to prediction of PrEP uptake behavior ( p < 0.001) in regression analysis. The maximum area under the ROC curve was 0.778 (95% IC: 0.739–0.817). Conclusion: The PrEP adherence questionnaire presented psychometric validation among STI patients.

Keywords: pre-exposure prophylaxis (PrEP); HIV prevention; questionnaire; adherence (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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