Partial Replacement of Dietary Fat with Polyunsaturated Fatty Acids Attenuates the Lipopolysaccharide-Induced Hepatic Inflammation in Sprague-Dawley Rats Fed a High-Fat Diet

Hee-Kyoung Son, Huo Xiang, Seohyun Park, Jisu Lee, Jae-Joon Lee, Sunyoon Jung and Jung-Heun Ha
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Hee-Kyoung Son: Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
Huo Xiang: Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
Seohyun Park: Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
Jisu Lee: Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
Jae-Joon Lee: Department of Food and Nutrition, Chosun University, Gwangju 61452, Korea
Sunyoon Jung: Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea
Jung-Heun Ha: Research Center for Industrialization of Natural Neutralization, Dankook University, Cheonan 31116, Korea

IJERPH, 2021, vol. 18, issue 20, 1-26

Abstract: In this study, we investigated whether the partial replacement of dietary fat with polyunsaturated fatty acids (PUFAs) ameliorated the lipopolysaccharide (LPS)-induced hepatic inflammation in rats fed a high-fat diet. Male Sprague-Dawley rats were divided into three groups and provided each of the following diets: (1) high-fat diet (HFD), (2) HFD with perilla oil (PO), and (3) HFD with corn oil (CO). After 12 weeks of dietary intervention, the rats were intraperitoneally injected with LPS (5 mg/kg) from Escherichia coli O55:B5 or phosphate-buffered saline (PBS). Following LPS stimulation, serum insulin levels were increased, while PO and CO lowered the serum levels of glucose and insulin. In the liver, LPS increased the triglyceride levels, while PO and CO alleviated the LPS-induced hepatic triglyceride accumulation. In the LPS injected rats, the mRNA expression of genes related to inflammation and endoplasmic reticulum (ER) stress was attenuated by PO and CO in the liver. Furthermore, hepatic levels of proteins involved in the nuclear factor kappa-light-chain-enhancer of activated B cells/mitogen-activated protein kinase pathways, antioxidant response, and ER stress were lowered by PO- and CO-replacement. Therefore, the partial replacement of dietary fat with PUFAs alleviates LPS-induced hepatic inflammation during HFD consumption, which may decrease metabolic abnormalities.

Keywords: high-fat diet; lipopolysaccharide; polyunsaturated fatty acids; perilla oil; corn oil; inflammation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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