Landfill Leachate from an Urban Solid Waste Storage System Produces Genotoxicity and Cytotoxicity in Pre-Adolescent and Young Adults Rats

Omar Ricardo Torres-González, Ivan Moisés Sánchez-Hernández, Mario Eduardo Flores-Soto, Verónica Chaparro-Huerta, Cesar Soria-Fregozo, Laura Hernández-García, Eduardo Padilla-Camberos and José Miguel Flores-Fernández
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Omar Ricardo Torres-González: Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of the State of Jalisco, A.C. (CIATEJ), Guadalajara 44270, Mexico
Ivan Moisés Sánchez-Hernández: Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of the State of Jalisco, A.C. (CIATEJ), Guadalajara 44270, Mexico
Mario Eduardo Flores-Soto: Laboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico
Verónica Chaparro-Huerta: Laboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico
Cesar Soria-Fregozo: Laboratorio Ciencias Biomédicas, Departamento de Ciencias de la Tierra y de la Vida, Centro Universitario de los Lagos, Universidad de Guadalajara, Lagos de Moreno 47460, Mexico
Laura Hernández-García: Department of Research and Innovation, Universidad Tecnológica de Oriental, Oriental 75020, Mexico
Eduardo Padilla-Camberos: Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of the State of Jalisco, A.C. (CIATEJ), Guadalajara 44270, Mexico
José Miguel Flores-Fernández: Department of Research and Innovation, Universidad Tecnológica de Oriental, Oriental 75020, Mexico

IJERPH, 2021, vol. 18, issue 21, 1-7

Abstract: Landfill leachate is a complex mixture of organic and inorganic molecules, as well as environmental pollutants that can cause harm to ecosystems and living beings. The micronucleus test in peripheral blood erythrocytes was used to evaluate the genotoxic and cytotoxic effects of exposure to a landfill leachate from an outdoor solid waste storage system on Wistar strain rats at different developmental stages, pre-adolescents and young adults, and the heavy metal content of the leachate was determined by atomic absorption spectrometry. Contents of arsenic, cadmium, chromium, mercury, and lead in the landfill leachate were outside the allowable international standards, and the exposure to the landfill leachate caused genotoxic and cytotoxic effects on Wistar rats, where the pre-adolescent animals were more susceptible to the toxics contained in the landfill leachate than young adults. Heavy metals contained in landfill leachate, individually or synergically with other molecules can be responsible for clastogenic and cytotoxic effects that can be harmful to humans and ecosystems.

Keywords: leachate; urban solid waste storage system; genotoxicity; cytotoxicity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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