Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review

Yoann Maitre, Rachid Mahalli, Pierre Micheneau, Alexis Delpierre, Gilles Amador and Frédéric Denis
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Yoann Maitre: Emergency Department, Montpellier University Hospital, 34090 Montpellier, France
Rachid Mahalli: Department of Odontology, Tours University Hospital, 37000 Tours, France
Pierre Micheneau: Department of Odontology, Tours University Hospital, 37000 Tours, France
Alexis Delpierre: Department of Odontology, Tours University Hospital, 37000 Tours, France
Gilles Amador: Faculty of Dentistry, Nantes University, 44000 Nantes, France
Frédéric Denis: Department of Odontology, Tours University Hospital, 37000 Tours, France

IJERPH, 2021, vol. 18, issue 21, 1-24

Abstract: This review aims to clarify the nature of the link between Alzheimer’s disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. We performed a systematic review, following the Preferred Reporting Items for Systematic Reviews checklist, from January 2000 to July 2021. The terms “plaque,” “saliva,” and “mouth” were associated with the search term “oral diseases” and used in combination with the Boolean operator “AND”/“OR”. We included experimental or clinical studies and excluded conferences, abstracts, reviews, and editorials. A total of 27 articles were selected. Evidence for the impact of the oral microbiome on the pathophysiological and immunoinflammatory mechanisms of Alzheimer’s disease is accumulating. The impact of the oral microbiome on the development of AD opens the door to complementary therapies such as phototherapy and/or the use of prebiotic compounds and probiotic strains for global or targeted modulation of the oral microbiome in order to have a favourable influence on the evolution of this pathology in the future.

Keywords: Alzheimer’s disease; oral microbiota; oral microbiome; mental disorders (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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