Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

Giovanni Damiani, Marco Alessandrini, Daniela Caccamo, Andrea Cormano, Gianpaolo Guzzi, Andrea Mazzatenta, Alessandro Micarelli, Alberto Migliore, Alba Piroli, Margherita Bianca, Ottaviano Tapparo and Paolo Daniele Maria Pigatto
Additional contact information
Giovanni Damiani: Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy
Marco Alessandrini: Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Daniela Caccamo: Department of Biomedical Sciences, Dental Sciences, & Morpho-Functional Imaging, Polyclinic Hospital University, 98124 Messina, Italy
Andrea Cormano: International Society of Doctors for Environment, 82100 Benevento, Italy
Gianpaolo Guzzi: Italian Association for Metals and Biocompatibility Research—A.I.R.M.E.B., 20122 Milan, Italy
Andrea Mazzatenta: Department of Neuroscience, Imaging and Clinical Science, ‘G. d’Annunzio’ University of Chieti-Pescara, 66100 Chieti, Italy
Alessandro Micarelli: Institute of Mountain Emergency Medicine, Eurac Research, 39100 Bolzano, Italy
Alberto Migliore: Department of Internal Medicine, Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, 00189 Rome, Italy
Alba Piroli: Department of MeSVA, University of L’Aquila, 67100 L’Aquila, Italy
Margherita Bianca: Patient with Multiple Chemical Sensitivity (MCS. The patient wanted to remain anonymous, so we decided to use a pseudonym).
Ottaviano Tapparo: Natrail Tagesklinik, 81925 Munchen, Germany
Paolo Daniele Maria Pigatto: Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy

IJERPH, 2021, vol. 18, issue 21, 1-19

Abstract: Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).

Keywords: multiple chemical sensitivity (MCS); chemical intolerance; threshold limit value; environmental exposure; neurogenic inflammation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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