Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis

Lysleine Alves Deus, Hugo de Luca Corrêa, Rodrigo Vanerson Passos Neves, Andrea Lucena Reis, Fernando Sousa Honorato, Victor Lopes Silva, Michel Kendy Souza, Thaís Branquinho de Araújo, Lucas Santos de Gusmão Alves, Caio Victor Sousa, Thaís Lucena Reis, Lucas Soares de Aguiar, Herbert Gustavo Simões, Jonato Prestes, Gislane Ferreira Melo and Thiago Santos Rosa
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Lysleine Alves Deus: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Hugo de Luca Corrêa: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Rodrigo Vanerson Passos Neves: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Andrea Lucena Reis: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Fernando Sousa Honorato: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Victor Lopes Silva: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Michel Kendy Souza: Department of Nephrology, Federal University of São Paulo, São Paulo 04021-001, Brazil
Thaís Branquinho de Araújo: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Lucas Santos de Gusmão Alves: Graduate Program in Medicine, Catholic University of Brasília, Brasília 71966-700, Brazil
Caio Victor Sousa: Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA
Thaís Lucena Reis: Medical Graduate Program, University of Brasília, Brasília 70910-900, Brazil
Lucas Soares de Aguiar: Medical Graduate Program, University of Brasília, Brasília 70910-900, Brazil
Herbert Gustavo Simões: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Jonato Prestes: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Gislane Ferreira Melo: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil
Thiago Santos Rosa: Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil

IJERPH, 2021, vol. 18, issue 21, 1-13

Abstract: Background: Hemodialysis patients are suffering from depressive symptoms. Brain-derived neurotrophic factor (BDNF) levels are negatively associated with depressive symptoms and decrease during a single hemodialysis session. Resistance training (RT) might be an additional non-pharmacological tool to increase BDNF and promote mental health. Methods: Two randomized groups of hemodialysis patients: control (CTL, n = 76/F36; 66.33 ± 3.88 years) and RT ( n = 81/F35; 67.27 ± 3.24 years). RT completed six months of training thrice a week under the supervision of strength and conditioning professional immediately before the dialysis session. Training loads were adjusted using the OMNI rating of perceived exertion. The total antioxidant capacity (TROLOX), glutathione (GSH), thiobarbituric acid reactive substance (TBARS), and BDNF levels were analyzed in serum samples. Quality of life (assessed through Medical Outcomes—SF36), and Beck Depression Inventory was applied. Results: RT improved handgrip strength (21.17 ± 4.38 vs. 27.17 ± 4.34; p = 0.001) but not for CTL (20.09 ± 5.19 vs. 19.75 ± 5.54; p = 0.001). Post-training, RT group had higher values as compared to CTL related to TROLOX (RT,680.8 ± 225.2 vs. CTL,589.5 ± 195.9; p = 0.001) and GSH (RT, 9.33 ± 2.09 vs. CTL,5.00 ± 2.96; p = 0.001). RT group had lower values of TBARS as compared to CTL at post-training (RT, 11.06 ± 2.95 vs. CTL, 13.66 ± 2.62; p = 0.001). BDNF increased for RT (11.66 ± 5.20 vs. 19.60 ± 7.23; p = 0.001), but decreased for CTL (14.40 ± 4.99 vs. 10.84 ± 5.94; p = 0.001). Quality of life and mental health increased ( p = 0.001) for RT, but did not change for CTL ( p = 0.001). BDNF levels were associated with emotional dimensions of SF36, depressive symptoms, and handgrip ( p = 0.001). Conclusions: RT was effective as a non-pharmacological tool to increased BDNF levels, quality of life, temper the redox balance and decrease depressive symptoms intensity in hemodialysis patients.

Keywords: quality of life; SF-36; redox balance; neuroprotection; depression (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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