Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study

Stefano Sartini, Laura Massobrio, Ombretta Cutuli, Paola Campodonico, Cristina Bernini (), Marina Sartini, Maria Luisa Cristina, Luca Castellani, Ludovica Ceschi, Marzia Spadaro, Angelo Gratarola and Paolo Barbera
Additional contact information
Stefano Sartini: Emergency Medicine Department, San Martino Policlinic University Hospital, 16132 Genoa, Italy
Laura Massobrio: Emergency Medicine Department, San Martino Policlinic University Hospital, 16132 Genoa, Italy
Ombretta Cutuli: Emergency Medicine Department, San Martino Policlinic University Hospital, 16132 Genoa, Italy
Paola Campodonico: Emergency Medicine Department, San Martino Policlinic University Hospital, 16132 Genoa, Italy
Marina Sartini: Department of Health Sciences, University of Genova, 16132 Genoa, Italy
Maria Luisa Cristina: Department of Health Sciences, University of Genova, 16132 Genoa, Italy
Luca Castellani: Emergency Medicine Post-Graduate School, University of Genoa, 16132 Genoa, Italy
Ludovica Ceschi: Emergency Medicine Post-Graduate School, University of Genoa, 16132 Genoa, Italy
Marzia Spadaro: Emergency Medicine Post-Graduate School, University of Genoa, 16132 Genoa, Italy
Angelo Gratarola: Division of Anesthesia and Intensive Care, San Martino Policlinic University Hospital, 16132 Genoa, Italy
Paolo Barbera: Emergency Medicine Department, San Martino Policlinic University Hospital, 16132 Genoa, Italy

IJERPH, 2021, vol. 18, issue 21, 1-13

Abstract: COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive for SARS-CoV-2. PaO2, PaO2/FiO2 and SatO2% were collected and analyzed at time 0 and in case of admission, patients who required or not C-PAP (groups A and B) were categorized. Each measurement was correlated to adverse outcome. A total of 483 patients were enrolled, and 369 were admitted to hospital. Of these, 153 required C-PAP and 266 had an adverse outcome. Patients with PaO2 <60 and >100 had a higher rate of adverse outcome at time 0, in groups A and B (OR 2.52, 3.45, 2.01, respectively). About the PaO2/FiO2 ratio, the OR for < 300 was 3.10 at time 0, 4.01 in group A and 4.79 in group B. Similar odds were found for < 200 in any groups and < 100 except for group B (OR 11.57). SatO2 < 94% showed OR 1.34, 3.52 and 19.12 at time 0, in groups A and B, respectively. PaO2 < 60 and >100, SatO2 < 94% and PaO2/FiO2 ratio < 300 showed at least two- to three-fold correlation to adverse outcome. This may provide simple but clear targets for clinicians facing COVID-19 respiratory failure in a non ICU-setting.

Keywords: COVID-19; respiratory failure; hyperoxia; hypoxia; non-invasive ventilation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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