Increased Prevalence of Atopic Dermatitis in Children Aged 0–3 Years Highly Exposed to Parabens

Johichi Arafune, Hiromasa Tsujiguchi, Akinori Hara, Yukari Shimizu, Daisuke Hori, Thao Thi Thu Nguyen, Fumihiko Suzuki, Toshio Hamagishi, Yohei Yamada, Haruki Nakamura, Takahiro Yoshikawa, Koichiro Hayashi, Aki Shibata, Yuma Fukutomi, Yukihiro Ohya, Kiwako Yamamoto-Hanada, Go Muto, Ryoji Hirota, Tadashi Konoshita, Yasuhiro Kambayashi and Hiroyuki Nakamura
Additional contact information
Johichi Arafune: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Hiromasa Tsujiguchi: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Akinori Hara: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Yukari Shimizu: Department of Nursing, Faculty of Health Sciences, Komatsu University, 14-1 Mukaimotorimachi, Komatsu 923-0961, Ishikawa, Japan
Daisuke Hori: Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan
Thao Thi Thu Nguyen: Faculty of Public Health, Haiphong University of Medicine and Pharmacy, Hai Phong 180000, Ngo Quyen, Vietnam
Fumihiko Suzuki: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Toshio Hamagishi: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Yohei Yamada: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Haruki Nakamura: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Takahiro Yoshikawa: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Koichiro Hayashi: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Aki Shibata: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Yuma Fukutomi: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Kanagawa, Japan
Yukihiro Ohya: Allergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan
Kiwako Yamamoto-Hanada: Allergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan
Go Muto: Department of Hygiene, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, Japan
Ryoji Hirota: The Graduate School of Health Science, Matsumoto University, 2095-1 Niimura, Matsumoto 390-1295, Nagano, Japan
Tadashi Konoshita: Third Department of Internal Medicine, University of Fukui Faculty of Medical Sciences, 23-3 Mat-suoka- Shimoaizaki, Eiheiji 910-1193, Fukui, Japan
Yasuhiro Kambayashi: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan
Hiroyuki Nakamura: Department of Environmental and Preventive Medicine, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan

IJERPH, 2021, vol. 18, issue 21, 1-10

Abstract: The prevalence of allergic diseases, such as bronchial asthma, atopic dermatitis, nasal allergies (pollinosis), and food allergies, has been increasing in many countries. The hygiene hypothesis was recently considered from the perspective of exposure to antimicrobial agents and preservatives, such as parabens (CAS number, 94-13-3). It currently remains unclear whether parabens, which are included in many daily consumer products such as cosmetics, shampoos, and personal care products as preservative antimicrobial agents, induce or aggravate allergies. Therefore, the aim of the present study was to examine the relationship between exposure to parabens and the prevalence of allergic diseases in Japanese children. The cross-sectional epidemiology of 236 children aged 0–3 years who underwent health examinations in Shika town in Japan assessed individual exposure to parabens using urinary concentrations of parabens. The results obtained showed that the prevalence of atopic dermatitis was significantly higher in children with high urinary concentrations of parabens than in those with low concentrations ( p < 0.001). This relationship remained significant after adjustments for confounding factors, such as age, sex, Kaup’s index, and passive smoking ( p < 0.001). In conclusion, the present results from a population study suggested a relationship between atopic dermatitis and exposure to parabens. A longitudinal study using a larger sample number and a detailed examination of atopic dermatitis, including EASI scores and exposure to parabens, will be necessary.

Keywords: allergy; atopic dermatitis; children; epidemiology; paraben (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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