In Vivo Imaging-Based Techniques for Early Diagnosis of Oral Potentially Malignant Disorders—Systematic Review and Meta-Analysis

Marta Mazur, Artnora Ndokaj, Divyambika Catakapatri Venugopal, Michela Roberto, Cristina Albu, Maciej Jedliński, Silverio Tomao, Iole Vozza, Grzegorz Trybek, Livia Ottolenghi and Fabrizio Guerra
Additional contact information
Marta Mazur: Department of Oral and Maxillo-Facial Sciences, Sapienza University, 00161 Rome, Italy
Artnora Ndokaj: Department of Oral and Maxillo-Facial Sciences, Sapienza University, 00161 Rome, Italy
Divyambika Catakapatri Venugopal: Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, India
Michela Roberto: Medical Oncology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University, 00161 Rome, Italy
Cristina Albu: Department of Oral and Maxillo-Facial Sciences, Sapienza University, 00161 Rome, Italy
Maciej Jedliński: Department of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 70111 Szczecin, Poland
Silverio Tomao: Medical Oncology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University, 00161 Rome, Italy
Iole Vozza: Department of Oral and Maxillo-Facial Sciences, Sapienza University, 00161 Rome, Italy
Grzegorz Trybek: Department of Oral Surgery, Pomeranian Medical University in Szczecin, 70111 Szczecin, Poland
Livia Ottolenghi: Department of Oral and Maxillo-Facial Sciences, Sapienza University, 00161 Rome, Italy
Fabrizio Guerra: Department of Oral and Maxillo-Facial Sciences, Sapienza University, 00161 Rome, Italy

IJERPH, 2021, vol. 18, issue 22, 1-22

Abstract: Objectives: Oral potentially malignant disorders (OPMDs) are lesions that may undergo malignant transformation to oral cancer. The early diagnosis and surveillance of OPMDs reduce the morbidity and mortality of patients. Diagnostic techniques based on medical images analysis have been developed to diagnose clinical conditions. This systematic review and meta-analysis aimed to evaluate the efficacy of imaging-based techniques compared to the gold standard of histopathology to assess their ability to correctly identify the presence of OPMDs. Design: Literature searches of free text and MeSH terms were performed using MedLine (PubMed), Scopus, Google Scholar, and the Cochrane Library (from 2000 to 30 June 2020). The keywords used in the search strategy were: (“oral screening devices” or “autofluorescence” or “chemiluminescence” or “optical imaging” or “imaging technique”) and (“oral dysplasia” or “oral malignant lesions” or “oral precancerosis”). Results: The search strategy identified 1282 potential articles. After analyzing the results and applying the eligibility criteria, the remaining 43 papers were included in the qualitative synthesis, and 34 of these were included in the meta-analysis. Conclusions: None of the analyzed techniques based on assessing oral images can replace the biopsy. Further studies are needed to explore the role of techniques-based imaging analysis to identify an early noninvasive screening method.

Keywords: imaging-based techniques; potentially malignant oral lesions; OPMD; diagnosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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