Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study

So Young Kim, Dae Myoung Yoo, Chanyang Min, Ji Hee Kim, Mi Jung Kwon, Joo-Hee Kim and Hyo Geun Choi
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So Young Kim: Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea
Dae Myoung Yoo: Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
Chanyang Min: Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
Ji Hee Kim: Department of Neurosurgery, Hallym University College of Medicine, Anyang 14068, Korea
Mi Jung Kwon: Department of Pathology, Hallym University College of Medicine, Anyang 14068, Korea
Joo-Hee Kim: Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University College of Medicine, Anyang 14068, Korea
Hyo Geun Choi: Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea

IJERPH, 2021, vol. 18, issue 22, 1-10

Abstract: The relationship between statin use and osteoporosis is controversial; therefore, this study aimed to investigate this association. The ?40-year-old population of the Korean National Health Insurance Service Health Screening Cohort was enrolled. The 68,592 osteoporosis patients were matched 1:1 with control participants for age, sex, income, and region of residence using propensity score matching. The histories of statin use for two years before the diagnosis of osteoporosis (index date) in the osteoporosis and control groups were compared using conditional/unconditional logistic regression. An increased number of days of statin use was not associated with osteoporosis (adjusted OR (aOR) = 0.97, 95% confidence interval (95% CI) = 0.94–1.00, p = 0.052). In the subgroup analyses, a large number of days of statin use was related to a reduced rate of osteoporosis in the <60-year-old female group, while the opposite was true in the ?60-year-old female group. Both lipophilic and hydrophilic statins were related to a decreased rate of osteoporosis in the <60-year-old female group. Lipophilic statins, but not hydrophilic statins, were associated with an increased rate of osteoporosis in the ?60-year-old female group. Statin use showed different associations in middle-aged and elderly women.

Keywords: osteoporosis; hydroxymethylglutaryl-CoA reductase inhibitors; risk factors; cohort studies (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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