Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population

Chun-Chi Hung, Yung-Wen Cheng, Wei-Liang Chen and Wen-Hui Fang
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Chun-Chi Hung: Department of Orthopaedic Surgery, Tri-Service General Hospital, Taipei 114, Taiwan
Yung-Wen Cheng: School of Medicine, National Defense Medical Center, Taipei 114, Taiwan
Wei-Liang Chen: School of Medicine, National Defense Medical Center, Taipei 114, Taiwan
Wen-Hui Fang: School of Medicine, National Defense Medical Center, Taipei 114, Taiwan

IJERPH, 2021, vol. 18, issue 22, 1-10

Abstract: Metabolic syndrome encompasses multiple conditions that increase the risk of cardiovascular disease, and exposure to environmental chemicals can cause metabolic syndrome. This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey (2003–2006) on 4318 adult participants to assess the association between acrylamide (AA) exposure and metabolic syndrome. Concentrations of hemoglobin-adducted AA (HbAA) and hemoglobin-adducted glycidamide (HbGA) were evaluated. Metabolic syndrome markers related to HbAA and HbGA and the effect of exposure to AA and GA on the prevalence of metabolic syndrome were studied by ANOVA and multivariate logistic regression analyses, respectively. HbAA concentration inversely correlated with the number of metabolic syndrome markers ( p < 0.05). An increased HbAA concentration was noted with reduced high triglyceride and low high-density lipoprotein cholesterol levels in the adjusted model ( p < 0.05). High fasting plasma glucose level significantly correlated with HbGA concentration in the adjusted model. In conclusion, AA exposure alters metabolic syndrome markers in adults. Additional clinical and animal studies will clarify the role of AA exposure at different stages in the progression of metabolic syndrome-related diseases.

Keywords: acrylamide; glycidamide; metabolic syndrome; NHANES (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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