Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia

Hyung-Jun Yoon, Seung-Gon Kim, Sang Hoon Kim, Jong Inn Woo, Eun Hyun Seo and For the Alzheimer’s Disease Neuroimaing Initiative
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Hyung-Jun Yoon: Department of Neuropsychiatry, College of Medicine, Chosun University/Chosun University Hospital, Gwangju 61452, Korea
Seung-Gon Kim: Department of Neuropsychiatry, College of Medicine, Chosun University/Chosun University Hospital, Gwangju 61452, Korea
Sang Hoon Kim: Department of Neuropsychiatry, College of Medicine, Chosun University/Chosun University Hospital, Gwangju 61452, Korea
Jong Inn Woo: Department of Neuropsychiatry, College of Medicine, Seoul National University Hospital, Seoul 03080, Korea
Eun Hyun Seo: Premedical Science, College of Medicine, Chosun University, Gwangju 61452, Korea
For the Alzheimer’s Disease Neuroimaing Initiative: For The Alzheimer’s Disease Neuroimaing Initiative is provided in the Acknowledgements.

IJERPH, 2021, vol. 18, issue 22, 1-11

Abstract: The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. We included participants with AD dementia from the Alzheimer’s Disease Neuroimaging Initiative, provided they were followed up at least once, and candidate proxies for cognitive (education for early-life reserve and Adult Reading Test for late-life reserve) or brain reserve (intracranial volume [ICV] for early-life reserve and the composite value of [ 18 F] fluorodeoxyglucose positron emission tomography regions of interest (FDG-ROIs) for late-life reserve) were available. The final analysis included 120 participants. Cox proportional hazards model revealed that FDG-ROIs were the only significant predictor of clinical progression. Subgroup analysis revealed a significant association between FDG-ROIs and clinical progression only in the larger ICV group (HR = 0.388, p = 0.028, 95% CI 0.167–0.902). Our preliminary findings suggest that relatively preserved cerebral glucose metabolism might delay further clinical progression in AD dementia, particularly in the greater ICV group. In addition to ICV, cerebral glucose metabolism could play an important role as a late-life brain reserve in the process of neurodegeneration. Distinguishing between early- and late-life reserves, and considering both proxies simultaneously, would provide a wider range of factors associated with the prognosis of AD dementia.

Keywords: Alzheimer’s disease; dementia; cognitive reserve; brain reserve; clinical progression; cerebral glucose metabolism (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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